- Clone
- QA20A58 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- alpha-chain of C3bi receptor, alphaM, C3bi receptor, CD11b, gp155/95, integrin a, M-chain, Mac-1
- Isotype
- Mouse IgG2a, κ
-
Human peripheral blood monocytes were stained with purified anti-human CD11b recombinant (clone QA20A58) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by PE goat anti-rat IgG.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 379902 | 100 µg | $124.00 | |||
CD11b (integrin alpha M subunit) is a type I transmembrane glycoprotein. CD11b combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/beta 2, also known as Mac-1 and complement receptor type 3 (CR3). Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen. CD11b is primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
The binding of clone QA20A58 can be completely blocked by reference clone.
Other anti-hCD11b clone ICRF44 does not affect the binding of clone QA20A58 to target. - RRID
-
AB_2910448 (BioLegend Cat. No. 379902)
Antigen Details
- Structure
- Integrin family, associates with integrin β2 (CD18), 170 kD
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells
- Function
- Adhesion, chemotaxis, phagocytosis, neutrophil activation
- Ligand/Receptor
- ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
- Cell Type
- B cells, Dendritic cells, Granulocytes, Neutrophils, NK cells, T cells, Tregs
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
- Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
- Springer TA. 1994. Cell. 76:301-14.
- Coxon A, et al. 1996. Immunity. 5:653-66.
- Gene ID
- 3684 View all products for this Gene ID
- UniProt
- View information about CD11b on UniProt.org
Other Formats
View All CD11b Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human CD11b Recombinant Antibody | QA20A58 | FC |
| Purified anti-human CD11b Recombinant Antibody | QA20A58 | FC |
| APC anti-human CD11b Recombinant Antibody | QA20A58 | FC |
| PE/Cyanine7 anti-human CD11b Recombinant Antibody | QA20A58 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-human CD11b Recombinant Antibody
Human peripheral blood monocytes were stained with anti-huma... -
Purified anti-human CD11b Recombinant Antibody
Human peripheral blood monocytes were stained with purified ... -
APC anti-human CD11b Recombinant Antibody
Human lysed whole blood (monocyte population) was stained wi... -
PE/Cyanine7 anti-human CD11b Recombinant Antibody
Human lysed whole blood (monocyte population) was stained wi...