- Clone
- QA18A49 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- 4-1BB, ILA, CD137, TNFRSF9
- Isotype
- Mouse IgG1, κ
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PHA-stimulated (3days) human peripheral blood mononuclear cells were stained with anti-human CD137 (4-1BB) recombinant (clone QA18A49) purified (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG APC. Cells were co-stained with CD3 PE.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 370902 | 100 µg | $129.00 | |||
CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Recombinant human CD137 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
QA18A49 clone of antibody is able to completely block the binding of clone 4B4-1 to CD137 on cell surface.
- RRID
-
AB_2890804 (BioLegend Cat. No. 370902)
Antigen Details
- Structure
- TNFR superfamily, type I transmembrane protein, 30 kD
- Distribution
-
Activated T cells
- Function
- T cell costimulation
- Ligand/Receptor
- 4-1BB ligand
- Cell Type
- Lymphocytes, NK cells, NKT cells, T cells
- Biology Area
- Adaptive Immunity, Costimulatory Molecules, Immuno-Oncology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Gruss HJ & Dower SK. 1995. Blood. 85:3378-404.
- Sica G & Chen L. 2000. Adv Exp Med Biol. 465:355-62.
- Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27.
- Schwarz H, et al. 1996. Blood. 87:2839-45.
- Gene ID
- 3604 View all products for this Gene ID
- UniProt
- View information about CD137 on UniProt.org
Other Formats
View All CD137 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD137 (4-1BB) Recombinant Antibody | QA18A49 | FC |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD137 (4-1BB) Recombinant Antibody
PHA-stimulated (3days) human peripheral blood mononuclear ce...