Purified anti-human CD267 (TACI) Antibody

Pricing & Availability
Clone
1A1 (See other available formats)
Regulatory Status
RUO
Other Names
TNFRSF13B, CD267, Transmembrane Activator and CAML Interactor (TACI)
Isotype
Rat IgG2a, κ
1A1_Pure_042606
Human TACI transfected cells stained with purified 1A1, followed by anti-rat IgGs-FITC
  • 1A1_Pure_042606
    Human TACI transfected cells stained with purified 1A1, followed by anti-rat IgGs-FITC
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Cat # Size Price Quantity Check Availability
311902 100 µg $206.00
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Description

TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.

Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
TACI-transfected RBL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al.2004. J. Immunol. 173:807. (FC)
  2. Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed.
Product Citations
  1. Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed
RRID
AB_528979 (BioLegend Cat. No. 311902)

Antigen Details

Structure
Type III transmembrane protein, TNF receptor superfamily, 32 kD
Distribution

B cells, meyloma cells

Function
Negative regulation of B cell function
Ligand/Receptor
BAFF/BLys, April, Syndecan-2
Cell Type
B cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Gross JA, et al. 2000. Nature 404:995.
2. Wu Y, et al. 2000. J. Biol Chem. 275:35478.
3. Yan M, et al. 2001. Nat. Immunol. 2:638.
4. Hymowitz A, et al. 2005. J. Biol. Chem. 280:7218.
5. Bischof D, et al. 2006. BLOOD 107:3235.

Gene ID
23495 View all products for this Gene ID
UniProt
View information about CD267 on UniProt.org
Go To Top Version: 2    Revision Date: 08/12/2022

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