Purified anti-human CD269 (BCMA) Antibody

Pricing & Availability
Clone
19F2 (See other available formats)
Regulatory Status
RUO
Other Names
BCM, TNFRSF17
Isotype
Mouse IgG2a, κ
19F2_Purified_CD269_Antibody_FC_032113
Human myeloma cell line U266 was stained with purified CD269 (clone 19F2, filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • 19F2_Purified_CD269_Antibody_FC_032113
    Human myeloma cell line U266 was stained with purified CD269 (clone 19F2, filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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357502 100 µg $265.00
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Description

CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells. It is expressed by plasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF and APRIL, and its cytoplasmic domain binds several of the TRAF family members.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BCMA-mouse IgG Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Marella M, et al. 2022. J Histochem Cytochem. 70:273. PubMed
  2. Thomas E, et al. 2022. Adv Healthc Mater. 11:e2101565. PubMed
RRID
AB_2561924 (BioLegend Cat. No. 357502)

Antigen Details

Structure
Single pass transmembrane protein, member of the TNFR superfamily, 1 TNFR-Cys domain, 27 kD
Distribution

Plasmablasts, plasma cells, germinal center B cells

Function
B cell maturation factor, essential for survival of plasma cells
Interaction
Associates with several TRAF family members
Ligand/Receptor
BAFF, APRIL
Cell Type
B cells, Plasma cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Coquery CM and Erickson LD. 2012. Crit. Rev. Immunol. 32:287. 
2. Notas G, et al. 2012. J. Immunol. 189:4748. 
3. Rickert RC, et al. 2011. Immunol. Rev. 244:115. 
4. Mesin L, et al. 2011. J. Immunol. 187:2867.

Gene ID
608 View all products for this Gene ID
UniProt
View information about CD269 on UniProt.org
Go To Top Version: 1    Revision Date: 04/05/2013

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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