Purified anti-human CD38 Antibody

Pricing & Availability
Clone
HB-7 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
HB7, T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
HB7_Purified_CD38_Antibody_FC_011713.jpg
Human peripheral blood lymphocytes were stained with purified CD38 (clone HB-7) (filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • HB7_Purified_CD38_Antibody_FC_011713.jpg
    Human peripheral blood lymphocytes were stained with purified CD38 (clone HB-7) (filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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Cat # Size Price Quantity Check Availability
356601 25 µg $54.00
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356602 100 µg $124.00
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BJAB human B cell line.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
ICC, WB - Reported in the literature, not verified in house
Recommended Usage

 Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Leader AM, et al. 2021. Cancer Cell. 39:1594. PubMed
  2. Schneider MM, et al. 2022. Life Sci Alliance. 5: . PubMed
  3. Poon MML, et al. 2023. Nat Immunol. 24:309. PubMed
  4. Simhadri VR, et al. 2013. J Innate Immun. 389:5. PubMed
  5. Shen W, et al. 2016. Front Immunol. 662:6. PubMed
  6. Gunawan M, et al. 2017. Sci Rep. . 10.1038/s41598-017-16999-7. PubMed
  7. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  8. Del Alcazar D, et al. 2019. Cell Rep. 28:3047. PubMed
  9. Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed
  10. Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed
  11. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_2561794 (BioLegend Cat. No. 356601)
AB_2561794 (BioLegend Cat. No. 356602)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK-cells, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org
Go To Top Version: 1    Revision Date: 01/28/2013

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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