Purified anti-human CD56 (NCAM) Recombinant Antibody

Pricing & Availability
Clone
QA18A21 (See other available formats)
Regulatory Status
RUO
Other Names
Leu-19, NKH1
Isotype
Mouse IgG1, κ
QA18A21_PURE_CD56_Recombinant_Antibody_1_021720.png
Human peripheral blood lymphocytes stained with purified recombinant CD56 (clone QA18A21) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 APC.
  • QA18A21_PURE_CD56_Recombinant_Antibody_1_021720.png
    Human peripheral blood lymphocytes stained with purified recombinant CD56 (clone QA18A21) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 APC.
  • QA18A21_PURE_CD56_Recombinant_Antibody_2_021720.png
    Human peripheral blood lymphocytes stained with purified recombinant CD56 (clone QA18A21) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD16 FITC.
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Cat # Size Price Quantity Check Availability
398802 100 µg $118.00
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Description

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2832780 (BioLegend Cat. No. 398802)

Antigen Details

Structure
Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution

NK cells, T subset, neural tissue, some LGL and myeloid leukemias

Function
Adhesion
Ligand/Receptor
Heparin sulfate
Cell Type
B cells, Leukemia, Mesenchymal Stem Cells, Neurons, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Rosental B, et al. 2011. J Immunol. 187:5693. PubMed
  2. Correia DV, et al. 2011. Blood. 118:992. PubMed
  3. Schlecker E, et al. 2014. Cancer Res. 74:3429. PubMed
  4. Snyder JM, et al. 2014. PLoS One. 9:e107257. PubMed
  5. Siebert N, et al. 2014. PLoS One. 9:e107692. PubMed
  6. Rider P, et al. 2015. J Immunol. 195:1705-12. PubMed
  7. Davis ZB, et al. 2011. J Vis Exp. 49: 2668. PubMed
  8. Robin JD, et al. 2015. J Vis Exp. 95: 52307. PubMed
  9. Ames E, et al. 2015. J Immunol. 195: 4010-9. PubMed
  10. Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed
  11. Pachnio A, et al. 2016. PLoS Pathog. 12:e1005832. PubMed
  12. Wouters K, et al. 2017. Sci Rep. 7:42665. PubMed
Gene ID
4684 View all products for this Gene ID
UniProt
View information about CD56 on UniProt.org
Go To Top Version: 1    Revision Date: 02/17/2020

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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