- Clone
- 94b/FOLR2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FR-BETA
- Isotype
- Mouse IgG1, κ
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Human peripheral blood leukocytes were stained with FR-β (94b/FOLR2) (left) or Mouse IgG1, κ isotype control (right), followed by goat-anti-mouse IgG PE and then costained with anti-CD14 APC. Data shown were from gated monocyte population.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 391702 | 100 µg | $241.00 | |||
Folate receptors beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Folate beta transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Nagayoshi R, et al. 2005. Arthritis Rheum. 9:2666
- RRID
-
AB_2715778 (BioLegend Cat. No. 391702)
Antigen Details
- Structure
- 30 kD, seven disulfide bonds
- Distribution
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Placenta, monocytes, tissue resident macrophages
- Function
- Transport of folate into cells
- Ligand/Receptor
- Folic Acid
- Cell Type
- Macrophages, Monocytes
- Biology Area
- Immunology
- Antigen References
-
- Elwood PC. 1989. J Biol Chem. 264:14893
- Shen F, et al. 1994. Biochemistry. 33:1209
- Yi YS. 2016. Immune Netw. 16:337
- Gene ID
- 2350 View all products for this Gene ID
- UniProt
- View information about Folate Receptor beta on UniProt.org
Other Formats
View All Folate Receptor β (FR-β) Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
| PE anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
| APC anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
| TotalSeq™-A0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
| TotalSeq™-B0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
| TotalSeq™-C0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human Folate Receptor β (FR-β)
Human peripheral blood leukocytes were stained with FR-β (94... -
PE anti-human Folate Receptor β (FR-β)
Human peripheral blood monocytes were stained with CD14 FITC... -
APC anti-human Folate Receptor β (FR-β)
Human peripheral blood monocytes were stained with CD14 FITC... -
TotalSeq™-A0427 anti-human Folate Receptor β (FR-β)
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TotalSeq™-B0427 anti-human Folate Receptor β (FR-β)
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TotalSeq™-C0427 anti-human Folate Receptor β (FR-β)