- Clone
- 124-40B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- UNC-43, BADLAMP, BAD-LAMP, C20orf103
- Isotype
- Mouse IgG1, κ
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Human peripheral blood mononuclear cells were surface stained with CD303 APC, fixed and permeabilized with BioLegend's FOXP3 Fix/Perm Buffer Set (Cat# 421403), and then stained with purified LAMP5 (clone 124-40B) (top) or mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 PE. -
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 355802 | 100 µg | $335.00 | |||
Lysosome-associated membrane protein 5 (LAMP5), also known as BAD-LAMP, UNC-43, and C20orf103, is a new member of LAMP family. It is a transmembrane glycosylated protein localized in the ER-Golgi intermediate compartment (ERGIC). LAMP5 shares sequence and structural homology with the canonical LAMP1 (CD107a) and LAMP2 (CD107b) molecules, harbors an endosomal addressing signal within its cytoplasmic tail, and contains several conserved cysteine residues that allow for the formation of particular structural loops known as LAMP folds. In mice, LAMP5 is expressed in postnatal cortical neurons of particular layers, where it is enriched in defined zones along neuronal projections. Human LAMP5, like its murine homolog, is principally expressed in brain; it is also specifically found in primary CD303 (BDCA-2)-positive pDCs (plasmacytoid dendritic cells). It represents a novel marker of human primary and transformed pDCs.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Cells expressing C20orf103.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining using our nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
-
View more applications data using a previous version of this product in our Scientific Poster Library.
- RRID
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AB_2561712 (BioLegend Cat. No. 355802)
Antigen Details
- Structure
- A transmembrane glycosylated protein
- Distribution
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pDCs
- Cell Type
- Dendritic cells
- Biology Area
- Immunology
- Antigen References
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1. Defays A, et al. 2011. Blood 118:609.
2. David A, et al. 2007. J. Cell. Sci. 120:353. - Gene ID
- 24141 View all products for this Gene ID
- UniProt
- View information about LAMP5 on UniProt.org
Other Formats
View All LAMP5 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human LAMP5 | 124-40B | ICFC |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human LAMP5
Human peripheral blood mononuclear cells were surface stain... 