- Clone
- MH3-2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor V beta 5
- Isotype
- Mouse IgG2a, κ
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Human peripheral blood lymphocytes stained with purified MH3-2 conjugated with Alexa Fluor® 647 and CD3 PE
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 349301 | 25 µg | $106.00 | |||
Vβ5 T cell receptor (TCR Vβ5) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ+ T cells. TCR α/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Patients with multiple sclerosis present an expansion of Vβ5.2+/5.3+ autoreactive T cells.
Product Details
- Verified Reactivity
- Human
- Reported Reactivity
- Pigtailed Macaque
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) - Product Citations
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- RRID
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AB_10643416 (BioLegend Cat. No. 349301)
Antigen Details
- Structure
- Immunoglobulin superfamily, associates with TCR Vα chain and CD3 complex
- Distribution
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Subset of TCR αβ+ T cells
- Function
- Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response
- Ligand/Receptor
- MHC-peptide complex
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
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1. Kuchroo VK, et al. 2002. Annu. Rev. Immunol. 20:101.
2. Venturi V, et al. 2008. Nat. Rev. Immunol. 8:231.
3. Matsumoto Y, et al. 2003. J. Immunol. 170:4846.
4. Killestein J, et al. 2002. Ann. Neurol. 51:467. - Gene ID
- 6957 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta5 on UniProt.org
Other Formats
View All TCR Vβ5 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human TCR Vβ5 | MH3-2 | FC |
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Purified anti-human TCR Vβ5
Human peripheral blood lymphocytes stained with purified MH3...