- Clone
- A17071D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-1 Rrp, CDw218a, IL-18 receptor a
- Isotype
- Rat IgG2b, κ
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C57BL/6 splenocytes were stained with CD3 PE and purified CD218a (IL-18Rα) (clone A17071D, left) or purified rat IgG2b, κ (right), followed by anti-rat IgG Alexa Fluor® 647.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 157902 | 500 µg | $457.00 | |||
The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD218a
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
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AB_2814095 (BioLegend Cat. No. 157902)
Antigen Details
- Structure
- An IL-1 receptor super family member
- Distribution
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Expressed on T cells, NK cell subset, neutrophils, IL-12 stimulated tonsillar B cells, and intestinal epithelial cells (IEC).
- Function
- Bind to pro inflammatory cytokine IL-18 and play an important role in innate and autoimmune responses.
- Ligand/Receptor
- IL-18
- Cell Type
- B cells, Endothelial cells, Neutrophils, NK cells, T cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- Parnet P, et al. 1996. J. Biol. Chem. 271:3967.
- Thomassen E, et al. 1998. J. Interferon Cytokine Res. 18:1077-88.
- Debets R, et al. 2000. J. Immunol. 165:4950-6.
- Smeltz RB, et al. 2001. J. Exp. Med. 194:143-53.
- Gene ID
- 16182 View all products for this Gene ID
- UniProt
- View information about CD218a on UniProt.org
Other Formats
View All CD218a Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD218a (IL-18Rα) | A17071D | FC |
| APC anti-mouse CD218a (IL-18Rα) | A17071D | FC |
| PE anti-mouse CD218a (IL-18Rα) | A17071D | FC |
| Alexa Fluor® 647 anti-mouse CD218a (IL-18Rα) | A17071D | FC |
| FITC anti-mouse CD218a (IL-18Rα) | A17071D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD218a (IL-18Rα)
C57BL/6 splenocytes were stained with CD3 PE and purified CD... -
APC anti-mouse CD218a (IL-18Rα)
C57BL/6 splenocytes were stained with CD3 PE and CD218a (IL-... -
PE anti-mouse CD218a (IL-18Rα)
C57BL/6 splenocytes were stained with CD3 APC and CD218a (IL... -
Alexa Fluor® 647 anti-mouse CD218a (IL-18Rα)
C57BL/6 splenocytes were stained with CD3 PE and CD218a (IL-... -
FITC anti-mouse CD218a (IL-18Rα)
C57BL/6 splenocytes were stained with anti-mouse CD3 PE and ...