- Clone
- N227/21 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Methyl-CpG-binding protein 2, meCp-2 protein, RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
814005 | 25 µg | 104€ | ||||
814006 | 100 µg | 169€ |
Methyl CpG binding protein (MECP2), also known as autism susceptibility to X-linked 2 (AUTSX3), is a nuclear protein crucial for normal neuronal function that binds to methylated DNA, forming complexes with histone deacteylases and turning off gene expression. MECP2 expression is an X-linked trait. Loss of MECP2 expression causes Rett Syndrome (also known as RTS, RTT, or RS) a neurological disorder which causes decelerated growth of hands, feet, and the head.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - RRID
-
AB_2750412 (BioLegend Cat. No. 814005)
AB_2750412 (BioLegend Cat. No. 814006)
Antigen Details
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Nuclear Markers
- Gene ID
- 4204 View all products for this Gene ID
- UniProt
- View information about MECP2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All MECP2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-MECP2 | N227/21 | IHC-P,ICC |
Alexa Fluor® 594 anti-MECP2 | N227/21 | IHC-P |
Alexa Fluor® 647 anti-MECP2 | N227/21 | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-MECP2
IHC staining of anti-MECP2 antibody (clone N227/21) on forma... IHC staining of anti-MECP2 antibody (clone N227/21) on forma... ICC staining of anti-MECP2 antibody (clone N227/21) on HeLa ... ICC staining of anti-MECP2 antibody (clone N227/21) on mouse... -
Alexa Fluor® 594 anti-MECP2
IHC staining of Alexa Fluor® 594 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 594 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 594 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 594 anti-MECP2 antibody (clone ... -
Alexa Fluor® 647 anti-MECP2
IHC staining of Alexa Fluor® 647 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 647 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 647 anti-MECP2 antibody (clone ... IHC staining of Alexa Fluor® 647 anti-MECP2 antibody (clone ...
Follow Us