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APC anti-human FcµR (FAIM3) Antibody

Pricing & Availability
Clone
HM7 (See other available formats)
Regulatory Status
RUO
Other Names
FcμR, FcmR, Fc mu receptor, IgM Fc receptor, FAIM3, TOSO
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
HM7_APC_FCuR_Antibody_1_051220
Human peripheral blood lymphocytes were stained with APC anti-human FCµR (clone HM7) (left) or mouse IgG2b, κ isotype ctrl (right) and PE/Cyanine7 CD19.
  • HM7_APC_FCuR_Antibody_1_051220
    Human peripheral blood lymphocytes were stained with APC anti-human FCµR (clone HM7) (left) or mouse IgG2b, κ isotype ctrl (right) and PE/Cyanine7 CD19.
See APC spectral data
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398103 25 tests 96€
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398104 100 tests 237€
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Description

The human FCMR (also known as FcμR, FAIM, TOSO) is a type 1 transmembrane glycoprotein that belonging to the immunoglobulin (Ig) gene superfamily. FCMR had a molecular weight of ~60 kD. Human FCMR is predominantly expressed by B, T, and NK cells, but not by monocytes, granulocytes, erythrocytes, and platelets. FCMR may play roles in regulating humoral immune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BW5147 cells expressing human FCMR protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

It was reported that HM7 antibody can block binding of human IgM to FCMR.

Application References
  1. Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
  2. Kubagawa H, et al. 2014. Monoclon Antib Immunodiagn Immunother. 33(6): 393– 400.
Product Citations
  1. Afsahi A, et al. 2023. Front Immunol. 14:1179827. PubMed
RRID
AB_2876722 (BioLegend Cat. No. 398103)
AB_2876722 (BioLegend Cat. No. 398104)

Antigen Details

Structure
~60 kD transmembranesialoglycoprotein extracellular Ig-like domain
Distribution

B and T lymphocytes, natural killer (NK) cells, chronic lymphocytic leukemia cells, some lymphoid leukemia or lymphoma cell lines

Function
Regulates both the cell surface expression and the function of BCR, regulates humoral immune responses
Ligand/Receptor
IgM Fc
Cell Type
B cells
Biology Area
Adaptive Immunity, Immunology, Signal Transduction
Molecular Family
Fc Receptors
Antigen References
  1. Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
  2. Shima H, et al. 2010. Int Immunol. 22(3): 149-56.
  3. Kubagawa H, et al. 2019. Front Immunol. 10:945.
  4. Meryk A, et al. 2019. Cell Rep. 26(10): 2681-91.
  5. Liu J, et al. 2019. Front Immunol. 10:529.
Gene ID
9214 View all products for this Gene ID
UniProt
View information about Fc muR on UniProt.org
Go To Top Version: 1    Revision Date: 04.16.2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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