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APC anti-mouse/rat XCR1 Recombinant Antibody

Pricing & Availability
Clone
QA20A05 (See other available formats)
Regulatory Status
RUO
Other Names
GPR5, CCXCR1, mXCR1, Lymphotactin receptor, SCM1 receptor, XC chemokine receptor 1
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
QA20A05_APC_XCR1_Antibody_121323
Cells from collagenase-digested C57BL/6 mouse spleen were stained with anti-mouse CD11c PE, anti-mouse CD8α FITC, and anti-mouse/rat XCR1 recombinant (clone QA20A05) APC (left) or rat IgG1, κ APC isotype control (right). Data shown was gated on the CD11c+ population.
  • QA20A05_APC_XCR1_Antibody_121323
    Cells from collagenase-digested C57BL/6 mouse spleen were stained with anti-mouse CD11c PE, anti-mouse CD8α FITC, and anti-mouse/rat XCR1 recombinant (clone QA20A05) APC (left) or rat IgG1, κ APC isotype control (right). Data shown was gated on the CD11c+ population.
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109407 25 µg 128€
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109408 100 µg 276€
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Description

XCR1, also known as GPR5 or CCXCR1, is a 38 kD, G-protein coupled, seven transmembrane receptor, and the only member of the "C" chemokine receptor family. XCR1 mediates chemotaxis of XCL1 and XCL2 (lymphotactin-1 and -2), and defines a subset of CD8α+ conventional dendritic cells capable of antigen cross-presentation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Rat
Antibody Type
Recombinant
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone QA20A05 can completely block the binding of clone ZET on target cells. 

RRID
AB_3097388 (BioLegend Cat. No. 109407)
AB_3097388 (BioLegend Cat. No. 109408)

Antigen Details

Structure
Only member of the "C" chemokine receptor family, seven transmembrane receptor, coupled to G protein, 38 kD.
Distribution

Subset of CD8α+  conventional dendritic cells.

Function
Mediates chemotaxis to XCL1, defines a population of CD8α+ dendritic cells capable of antigen cross-presentation to CD8+ T cells.
Ligand/Receptor
XCL1 and XCL2
Antigen References
  1. Yamazaki C, et al. 2013. J Immunol. 190:6071-82.
  2. Shimizu K, et al. 2013. J Immunol. 190:5609-19.
  3. Bachem A, et al. 2012. Front Immunol. 3:214.
  4. Crozat K, et al. 2011. J Immunol. 187:4411-5.

 

Gene ID
23832 View all products for this Gene ID 301086 View all products for this Gene ID
UniProt
View information about XCR1 on UniProt.org
Go To Top Version: 1    Revision Date: 12.13.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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