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PE anti-human NKp80 Antibody

Pricing & Availability
Clone
5D12 (See other available formats)
Regulatory Status
RUO
Other Names
KLRF1, killer cell lectin-like receptor subfamily F, member 1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
A_5D12_PE_011310
Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • A_5D12_PE_011310
    Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • B_5D12_PE_011310
Compare all formats See PE spectral data
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346706 100 tests 244€
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Description

NKp80, also known as killer cell lectin-like receptor subfamily F, member 1 (KLRF1), is a type II transmembrane C-type lectin-like receptor. NKp80 is expressed on the cell surface of nearly all NK cells as a homodimer with approximately 80 kD molecular mass. It is also found on a subset of effector memory CD8 T cells and γ/δ T cells. NKp80 induces NK-cell mediated cytotoxicity and cytokine production through interaction with its ligand, AICL (activation-induced C-type lectin), which is selectively expressed on myeloid cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant ectodomain of human NKp80
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References
  1. Welte S, et al. 2006. Nat. Immunol. 7:1334.
  2. Kuttruff S, et al. 2009. Blood 113:358.
Product Citations
  1. Loyon R, et al. 2016. J Immunol. 197: 85 - 96. PubMed
  2. Gerace D, et al. 2023. Cell Rep Med. 4:100879. PubMed
  3. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  4. Manser AR, et al. 2019. J Immunol. 203:2301. PubMed
  5. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
RRID
AB_1967147 (BioLegend Cat. No. 346706)

Antigen Details

Structure
Type II transmembrane c-type lectin-like receptor, homodimer, 80 kD
Distribution

NK cells, subset of CD8 T and γ/δ T cells

Ligand/Receptor
AICL (activation-induced C-type letcin)
Bioactivity
induce NK cell-mediated cytolysis and cytokine release
Cell Type
NK cells, T cells
Biology Area
Costimulatory Molecules, Immunology, Innate Immunity
Antigen References

1. Kuttruff S, et al. 2009. Blood 113:358
2. Vitale M, et al. 2001. Eur. J. Immunol. 31:233

Gene ID
51348 View all products for this Gene ID
UniProt
View information about NKp80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08.23.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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