- Clone
- W19330C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CSF-1R, M-CSR, c-fms
- Isotype
- Rat IgG2a, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
165003 | 25 µg | 84€ | ||||
165004 | 100 µg | 203€ |
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Moue CD115 transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Clone W19330C does not affect binding of clone W19330E or clone AFS98 on the target.
- RRID
-
AB_2910350 (BioLegend Cat. No. 165003)
AB_2910350 (BioLegend Cat. No. 165004)
Antigen Details
- Structure
- Ig superfamily, 145 kD
- Distribution
-
Monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, osteoclasts
- Function
- Growth factor receptor, tyrosine kinase
- Ligand/Receptor
- Macrophage colony stimulating factor (M-CSF), IL-34
- Cell Type
- Dendritic cells, Macrophages, Monocytes, Osteoclasts
- Biology Area
- Cell Biology, Immunology, Stem Cells
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
- Guilbert LJ and Stanley ER. 1980. J Cell Biol. 85:153-9.
- Yeung YG, et al. 1978. Proc Natl Acad Sci U S A. 84:1268-71.
- Sherr CJ, et al. 1985. Cell. 41:665-76.
- Gene ID
- 12978 View all products for this Gene ID
- UniProt
- View information about CD115 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD115 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-mouse CD115 (CSF-1R) | W19330C | FC |
Purified anti-mouse CD115 (CSF-1R) | W19330C | FC |
APC anti-mouse CD115 (CSF-1R) | W19330C | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-mouse CD115 (CSF-1R)
Thioglycolate-elicited BALB/c mouse peritoneal macrophages w... -
Purified anti-mouse CD115 (CSF-1R)
Thioglycolate-elicited BALB/c mouse peritoneal macrophages w... -
APC anti-mouse CD115 (CSF-1R)
Thioglycolate-elicited BALB/c mouse peritoneal macrophages w...
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