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PE anti-mouse MAIR-V Antibody

Pricing & Availability
Clone
TX70 (See other available formats)
Regulatory Status
RUO
Other Names
CD300LF, CD300f, CMRF35-like molecule 1, Myeloid-associated immunoglobulin-like receptor 5
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
TX70_PE_021009.jpg
MAIR-V transfected cells stained with TX70-PE
  • TX70_PE_021009.jpg
    MAIR-V transfected cells stained with TX70-PE
See PE spectral data
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132704 100 µg 259€
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Description

The myeloid-associated immunoglobulin-like receptor family (CD300) consists of nine activating or inhibitory cell surface receptors preferentially expressed on myloid cells and are encoded by the genes in a small cluster on mouse chromosome 11. MAIR-V is one of the family members. MAIR-V regulates the activation of myeloid cells. It has been reported that cross-linking MAIR-V with anti-MAIR-V monoclonal antibody induced cell death in peritoneal macrophages as well as transfectants. Data suggested that MAIR-V is one of the inhibitory receptors in the family. The functional of characteristics of this receptor are still not clear. Monoclonal antibody TX70 recognized both MAIR-Va and MAIR-Vb.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
MAIR-V transfectant (BW5147)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.015 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Graziano VR, et al. 2020. PLoS Pathog. 16:e1008242. PubMed
RRID
AB_2074116 (BioLegend Cat. No. 132704)

Antigen Details

Structure
MAIR-V belongs to the myeloid-associated immunoglobulin-like receptor family. It has two isoforms, MAIR-Va and MAIR-Vb. MAIR-V contains a consensus immunoreceptor tyrosine-based switching motif (ITSM) as well as two ITIMs in the cytoplasmic tail.
Distribution
It was reported that CD300LF is expressed on myeloid cells, including macrophages, neutrohils, DCs, and bone marrow derived mast cells. The expression profile of MAIR-V is still incompletely understood.
Cell Type
Macrophages, Neutrophils, Dendritic cells, Mast cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Can Ismail, et al. 2008. Hybridoma. 27 (1):59-61
2. Can Ismail, et al. 2008. J. Immunol. Sep; 180:207-213
3. Totsumoto K, et al. 2003. J. Exp. Med. 198:223-233

Gene ID
246746 View all products for this Gene ID
UniProt
View information about MAIR-V on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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