- Clone
- DSG3/5H10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- DSG3, PVA
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
871901 | 25 µg | 85€ | ||||
871902 | 100 µg | 221€ |
Desmoglein-3 is a glycoprotein mainly expressed in the basal lower layers of the epidermis and on mucosal surfaces. It is the Ca2+ binding transmembrane components of the desmosomes that functions as cell-cell junctions between epithelial cells as well as other cell types. Clinically, desmoglein-3 has been identified as one of the autoantigens in the autoimmune skin blistering disease pemphigus vulgaris. It also serves as a prognostic marker of esophageal squamous cell carcinoma.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg/mL. For immunocytochemistry, a concentration range of 2.0 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
-
- Wan H, et al. 2016. Data Brief. 6:124-34 (WB, ICC)
- Walter E, et al. 2017. Sci Rep. 7:3579 (ICC)
- Tsang SM, et al. 2010. PloS One. 5:e14211 (WB, ICC)
- RRID
-
AB_2876750 (BioLegend Cat. No. 871901)
AB_2876750 (BioLegend Cat. No. 871902)
Antigen Details
- Structure
- Desmoglein 3 is a 999 amino acid protein with predicted molecular mass of 108 kD and observed molecular mass of ~130 kD.
- Distribution
-
Tissue Distribution: Esophagus, skin, tonsil
Cellular Distribution: Plasma membrane, cytosol, extracellular - Function
- Desmoglein-3 is the Ca2+ binding transmembrane components of the desmosomes that functions as cell-cell junctions between epithelial cells as well as other cell types.
- Interaction
- PKP3, JUP, WWOX, FRMD1, OAZ3
- Cell Type
- Endothelial cells, Epithelial cells
- Biology Area
- Adaptive Immunity, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Signal Transduction
- Molecular Family
- Adhesion Molecules, Gap Junction Proteins
- Antigen References
-
- Mahmoudi H, et al. 2020. Int J Immunogenet. 47:41-9
- Spindler V & Waschke J. 2018. Front immunol. 9:136
- Pan M, et al. 2015. J Dermatol. 42:11-7
- Gene ID
- 1830 View all products for this Gene ID
- UniProt
- View information about Desmoglein 3 on UniProt.org
Related FAQs
Other Formats
View All Desmoglein 3 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Desmoglein 3 | DSG3/5H10 | WB,ICC |
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