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Purified anti-human CD130 (gp130) Antibody

Pricing & Availability
Clone
2E1B02 (See other available formats)
Regulatory Status
RUO
Other Names
GP130, GP-130, IL6ST, IL-6Rβ, Oncostatin M Receptor, Oncostatin-M receptor subunit alpha
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
2E1B02_Purified_CD130_Antibody_FC_022014.jpg
Human peripheral blood lymphocytes were stained with purified CD130 (clone 2E1B02) (solid line) or purified mouse IgG2a, κ Alexa Fluor® 647 isotype control (dashed line), followed by anti-mouse IgG PE.
  • 2E1B02_Purified_CD130_Antibody_FC_022014.jpg
    Human peripheral blood lymphocytes were stained with purified CD130 (clone 2E1B02) (solid line) or purified mouse IgG2a, κ Alexa Fluor® 647 isotype control (dashed line), followed by anti-mouse IgG PE.
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362002 100 µg 100€
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Description

CD130, also known as gp130 (glycoprotein 130), IL6ST (IL-6-receptor-associated signal transducer), or common β chain, is a member of the hematopoietic cytokine receptor family. CD130 is a common subunit associated with the receptors for several cytokines, such as IL-6, IL-11, Oncostatin M (OSM), CNTF (ciliary neurotrophic factor), CT-1, Neuropoietin (NP), and IL-27. CD130 participates in the JAK-STAT signaling pathway and is expressed on T cells, activated B cells, monocytes, plasma cells, and endothelial or epithelial cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
GP130 (23-619aa) recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2563186 (BioLegend Cat. No. 362002)

Antigen Details

Structure
130 kD type I transmembrane glycoprotein.
Distribution

T cells, activated B cells, monocytes, plasma cells, endothelial cells and epithelial cells.

Function
Common β subunit of IL-6 receptor family, plays a role in signal transduction.
Ligand/Receptor
IL-6, IL-11, OSM, CNTF, CT-1, NP, IL-27.
Cell Type
B cells, Endothelial cells, Epithelial cells, Monocytes, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Arzt E, et al. 2001. J. Clin. Invest. 108:1729.
2. Bravo J, et al. 2000. EMBO J. 19:2399.
3. Wang XJ, et al. 1998. Blood 91:3308.
4. Hibi. M, et al. 1990. Cell. 63:1149.
5. Schlossman S, et al. 1995. ed. Leukocyte Typing V. New York. Oxford University Press.

Gene ID
3572 View all products for this Gene ID
UniProt
View information about CD130 on UniProt.org
Go To Top Version: 1    Revision Date: 02.21.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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