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- Clone
- S22039A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD158a, Killer Cell Immunoglobulin-Like Receptor 2DL1, NKAT1, p58.1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human peripheral blood lymphocytes were stained with purified anti-human CD158a (KIR2DL1) (clone S22039A) (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG PE. Cells were then stained with anti-human CD56 (clone QA17A16) APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 316414 | 100 µg | 82€ | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.
CD158a, also known as KIR2DL1, is a 38 kD, two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL1 has been reported to bind certain HLA-C antigens on target cells (HLA-C*02, HLA-C*04, HLAC*06, for example).
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human KIR2DL1 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S22039A does not block binding of clones HP-DM1 and HP-MA4 on target cells.
Based on in-house testing on different KIR-expressing transfectants, clone S22039A does not interact with other KIR protein family members.
Antigen Details
- Structure
- 38 kD two Ig-like extracellular domain glycoprotein
- Distribution
-
Subset of NK cells, subset of T Cells
- Function
- NK cell regulation
- Ligand/Receptor
- Some HLA-C molecules
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
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- Vilches C, et al. 2002. Annu Rev Immunol. 92.107361.
- Middleton, D. et al. 2010. Immunol. 123:8.
- Fan QR. et al. 2004. Blood. 103:5.
- Gene ID
- 3802 View all products for this Gene ID
- UniProt
- View information about CD158a on UniProt.org
Related FAQs
Other Formats
View All CD158a Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD158a (KIR2DL1) | S22039A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD158a (KIR2DL1)
Human peripheral blood lymphocytes were stained with purifie...
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