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Purified anti-human CD339 (Jagged 1) Antibody

Pricing & Availability
Clone
W16199B (See other available formats)
Regulatory Status
RUO
Other Names
JAG1, Jag-1, Jagged1, Jagged-1
Isotype
Rat IgG2a, κ
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Product Citations
publications
W16199B_PURE_CD339_Antibody_022620.png
Human U251 glioblastoma cells were stained with purified CD339 (Jagged 1) (clone W16199B) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • W16199B_PURE_CD339_Antibody_022620.png
    Human U251 glioblastoma cells were stained with purified CD339 (Jagged 1) (clone W16199B) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
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399102 100 µg 141€
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Description

CD339, also known as Jagged 1, is a 135 kDa type 1 transmembrane protein with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. Jagged 1 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Some studies suggest Jagged 1 is also involved in Th2 polarization and Treg induction.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human Jagged-transfected RBL1 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2832781 (BioLegend Cat. No. 399102)

Antigen Details

Structure
A 135 kD type 1 transmembrane protein with 1 DSL domain, 15 EGF-like domain and 1 cysteine-rich region.
Distribution

Macrophages, subset of dendritic cells, astrocytes, stromal and epithelial cells.

Function
Regulate cell fate decisions in tissues, neurogenesis, Th2 polarization, and Treg induction
Ligand/Receptor
Notch
Cell Type
Astrocytes, Dendritic cells, Epithelial cells, Macrophages, Monocytes
Biology Area
Cardiovascular Biology, Immunology, Neuroscience
Molecular Family
CD Molecules
Antigen References
  1. Oda T, et al. 1997. Nat. Genet. 16:235.
  2. Li L, et al. 1997. Nat. Genet. 16:243.
  3. Guarnaccia C, et al. 2004. FEBS Letters. 574:156.
  4. High FA, et al. 2008. Proc. Natl. Acad. Sci. 105:1955.
  5. Kopan R and Ilagan MX. 2009. Cell. 137:216.
  6. Reedijk M, et al. 2005. Cancer Res. 65:8530.
  7. Grochowski CM, et al. 2016. Gene. 576:381.
  8. Hofmann JJ, et al. 2012. Development. 139:4449.
Gene ID
182 View all products for this Gene ID
UniProt
View information about CD339 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 02.26.2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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