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Purified anti-human MRGX2 Antibody

Pricing & Availability
Clone
K125H4 (See other available formats)
Regulatory Status
RUO
Other Names
Mas-related G-protein coupled receptor member X2, MRGPRX2
Isotype
Mouse IgG2b, κ
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Product Citations
publications
K125H4_Purified_MRGX2_Antibody_FC_070313
Human MRGX2 transfected CHO cells were stained with purified MRGX2 (clone K125H4, filled histogram) or purified mouse IgG2b, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • K125H4_Purified_MRGX2_Antibody_FC_070313
    Human MRGX2 transfected CHO cells were stained with purified MRGX2 (clone K125H4, filled histogram) or purified mouse IgG2b, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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359002 100 µg 268€
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Description

MRGX2 (Mas-related G-protein coupled receptor member X2) is a 36 kD, seven transmembrane protein expressed on mast cells and sensory neurons from the dorsal root ganglia. MRGX2 is involved in mast cell-degranulation, and may regulate the function and development of sensory neurons. Originally described as an orphan receptor, it has been reported MRGX2 binds defensins and costistatin.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
DNA vaccine containing the full length gene of human MRGX2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Babina M, et al. 2021. Cells. 10: . PubMed
  2. Lazki-Hagenbach P, et al. 2022. Front Immunol. 13:892239. PubMed
  3. Chompunud Na Ayudhya C, et al. 2021. Int J Mol Sci. 22: . PubMed
  4. Lazki-Hagenbach P, et al. 2021. Cells. :10. PubMed
  5. Plum T, et al. 2020. Immunity. 52(2):404-416. PubMed
RRID
AB_2562299 (BioLegend Cat. No. 359002)

Antigen Details

Structure
Seven transmembrane domains, 36 kD, member of the GPCR family
Distribution

Mast cells, sensory neurons from the dorsal root ganglia

Function
Involved in mast cell-degranulation, may regulate function and development of sensory neurons
Interaction
Coupled to G-proteins Gαq and Gαi
Ligand/Receptor
Defensins, cortistatin
Cell Type
Mast cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Subramanian H, et al. 2013. J. Immunol. 191:345.
2. Subramanian H, et al. 2011. J. Biol. Chem. 286:44739. 
3. Yang S, et al. 2005. Gene. 352:30.
4. Robas N, et al. 2003. J. Biol. Chem. 278:44400.

Gene ID
117194 View all products for this Gene ID
UniProt
View information about MRGX2 on UniProt.org
Go To Top Version: 1    Revision Date: 07.16.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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