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Purified anti-human TCR Vβ13.1 Antibody

Pricing & Availability
Clone
H131 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor Vβ13.1 chain, TCRBV13.1, TCRBV13
Isotype
Mouse IgG2b, κ
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Product Citations
publications
H131_Purified_TCR_Vbeta13.1_FC_1_051514
Human peripheral blood lymphocytes were stained with CD3 APC and TCR Vβ13.1 (clone H131) purified (top) or mouse IgG2b, κ purified isotype control (bottom), followed by anti-mouse IgG2b (clone RMG2b-1) FITC.
  • H131_Purified_TCR_Vbeta13.1_FC_1_051514
    Human peripheral blood lymphocytes were stained with CD3 APC and TCR Vβ13.1 (clone H131) purified (top) or mouse IgG2b, κ purified isotype control (bottom), followed by anti-mouse IgG2b (clone RMG2b-1) FITC.
  • H131_Purified_TCR_Vbeta13.1_FC_2_051514
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362402 100 µg 100€
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Description

TCR Vβ13.1 is a variant of the TCR β chain. The receptor is complexed with the TCR α chain and belongs to the immunoglobulin superfamily. It is expressed on a subset of T cells and some T cell clones. Variability in the β chain is generated by Vβ, Dβ, and Jβ gene rearrangement, while variability in the α chain is generated by Vα and Jα rearrangement. TCR Vβ13.1 has been shown to be related to antigen recognition and inflammation as well as diseases, such as HIV and multiple sclerosis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse T cell hybridoma
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Activ - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats of this clone) include: activation of TCR Vß13.1 expressing cells1.

Application References
  1. Choi YW, et al. 1991. Proc. Natl. Acad. Sci. USA 88:8357.
Product Citations
  1. Li F, et al. 2022. Nat Commun. 13:4334. PubMed
RRID
AB_2563503 (BioLegend Cat. No. 362402)

Antigen Details

Structure
Immunoglobulin superfamily
Distribution

Subset of T cells

Function
Antigen recognition, activation of TCR Vβ13.1 bearing T cells
Ligand/Receptor
Peptide bound MHC molecules
Cell Type
T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
TCRs
Antigen References

1. Hong J, et al. 1999. J. Immunol. 163:3530.
2. Jason J, et al. 1997. Scand. J. Immunol. 45:81.
3. Chang JC, et al. 1995. Ann. NY. Acad. Sci. 756:370.
4. Miyahara E, et al. 1999. Anticancer Res. 19:2057.
5. Usuku K, et al. 1993. Immunogenetics. 38:193.
6. Bakakos P, et al. 2002. Clin. Exp. Immunol. 129:370.

Gene ID
6957 View all products for this Gene ID
UniProt
View information about TCR Vbeta13.1 on UniProt.org
Go To Top Version: 1    Revision Date: 05.28.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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