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- Clone
- A17002B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- V-Set Immunoregulatory Receptor (VSIR), B7H5, GI24, B7-H5, Dies1, PD-1H, SISP1, VISTA, PP2135, C10orf54, DD1alpha
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes were stained with purified anti-human VISTA (PD-1H) (clone A17002B) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram). Cells were then stained with goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 378102 | 100 µg | 272€ | ||||
VISTA (V-domain Ig suppressor of T cell activation), also known as PD-1H, is a type I transmembrane protein with a single extracellular IgV domain. VISTA is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It was reported that in certain tumor environment, there is low-pH dependent interaction between VISTA and PSGL1. However, the physiological binding partner for VISTA and the mechanism of its action are not clearly understood. VISTA is considered as a checkpoint regulator and a promising target for cancer immunotherapy.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human VISTA protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC – Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2910435 (BioLegend Cat. No. 378102)
Antigen Details
- Structure
- Ig V-domain like
- Distribution
-
Hematopoietic cells, monocytes, macrophages, dendritic cell, granulocytes, subsets of T cells
- Function
- Suppressing T cell activation
- Cell Type
- Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes, T cells
- Biology Area
- Immunology, Inhibitory Molecules
- Antigen References
-
- Wang Li, et al. 2011. J Exp Med. 208:577-92.
- Nowak EC, et al. 2017. Immunol Rev. 276:66-79.
- Flies DB, et al. 2014. J Clin Invest. 124:1966-75.
- Gene ID
- 64115 View all products for this Gene ID
- UniProt
- View information about VISTA on UniProt.org
Other Formats
View All VISTA Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human VISTA (PD-1H) | A17002B | FC |
| TotalSeq™-C1457 anti-human VISTA (PD-1H) | A17002B | PG |
| TotalSeq™-A1457 anti-human VISTA (PD-1H) | A17002B | PG |
| TotalSeq™-B1457 anti-human VISTA (PD-1H) | A17002B | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human VISTA (PD-1H)
Human peripheral blood monocytes were stained with purified ... -
TotalSeq™-C1457 anti-human VISTA (PD-1H)
-
TotalSeq™-A1457 anti-human VISTA (PD-1H)
-
TotalSeq™-B1457 anti-human VISTA (PD-1H)
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