- Clone
- H155-78 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Lymphocyte function-associated antigen 1, ITGAL, ITGB2
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
141002 | 500 µg | 184€ |
Lymphocyte function-associated antigen 1 or LFA-1 is a heterodimer composed of two members of the integrin family, αL (CD11a) and β2 (CD18). LFA-1 is expressed primarily on lymphocytes, monocytes/macrophages, and granulocytes. It is involved in cell adhesion and costimulation processes. The ligands for LFA-1 are ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- TH-derived anti-I-Ak CTL clone A1 5.1.17
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone is reported to have some effect on increasing LFA-1-mediated adhesion and does not block LFA-1 binding1.
- Application References
-
- Pont S, et al. 1986. J. Immunol. 136:3750. (FC)
- Product Citations
-
- RRID
-
AB_10694866 (BioLegend Cat. No. 141002)
Antigen Details
- Structure
- Heterodimer composed of two members of the integrin family, &alphaL (CD11a) and β2 (CD18).
- Distribution
-
Primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes
- Function
- Intercellular adhesion and costimulation
- Ligand/Receptor
- ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), and ICAM-3 (CD242)
- Cell Type
- B cells, Dendritic cells, Lymphocytes, Macrophages, Monocytes
- Biology Area
- Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Signal Transduction
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Dugger KJ, et al. 2009. J. Neuroimmunol. 206:22.
2. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
3. Springer TA. 1994. Cell 76:301.
4. Lub M, et al. 1995. Immunol. Today 16:479. - Gene ID
- 16408 View all products for this Gene ID 16414 View all products for this Gene ID
- UniProt
- View information about CD11a CD18 on UniProt.org
Related FAQs
Other Formats
View All CD11a/CD18 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PerCP/Cyanine5.5 anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
Purified anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
PE anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
APC anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
PE/Cyanine7 anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
Pacific Blue™ anti-mouse CD11a/CD18 (LFA-1) | H155-78 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PerCP/Cyanine5.5 anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 splenocytes were stained with LFA-1 (clone H155-78) ... -
Purified anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 splenocytes were stained with LFA-1 (clone H155-78) ... -
PE anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 mouse splenocytes were stained with H155-78 PE and r... C57BL/6 mouse splenocytes were stained with CD11a/CD18 (clon... -
APC anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 splenocytes were stained with LFA-1 (clone H155-78) ... -
PE/Cyanine7 anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 splenocytes were stained with LFA-1 (clone H155-78) ... -
Pacific Blue™ anti-mouse CD11a/CD18 (LFA-1)
C57BL/6 mouse splenocytes were stained with CD11a/CD18 (LFA-...
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