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Purified anti-Thyroglobulin Antibody

Pricing & Availability
Clone
BSB-49 (See other available formats)
Regulatory Status
RUO
Other Names
Tg
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
BSB-49_PURE_Thyroglobulin_IHCP_113018
IHC staining of purified anti-Thyroglobulin antibody (clone BSB-49) on formalin-fixed paraffin-embedded human thyroid tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/ml of the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
  • BSB-49_PURE_Thyroglobulin_IHCP_113018
    IHC staining of purified anti-Thyroglobulin antibody (clone BSB-49) on formalin-fixed paraffin-embedded human thyroid tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/ml of the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
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846902 100 µg 231€
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Description

Thyroglobulin (Tg) is a dimeric glycoprotein that is predominantly produced by follicular cells of the thyroid. This protein is secreted from the endoplasmic reticulum to the follicular lumen. Tg acts as a substrate for the synthesis of thyroxine (T4) and triiodothyronine (T3) as well as storage of inactive forms of thyroid hormone and iodine.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human thyroglobulin protein.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

IHC-P - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2629663 (BioLegend Cat. No. 846902)

Antigen Details

Structure
Thyroglobulin is a 2768 amino acid protein with a molecular mass of 305 kD.
Distribution

Tissue distribution: thyroid.
Cellular distribution: extracellular, endoplasmic reticulum and plasma membrane.

Function
Thyroglobulin is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Interaction
HSPA5
Biology Area
Cell Biology, Neuroscience
Molecular Family
Hormones
Antigen References

1. Ma ZF, Skeaff SA. 2014. Thyroid 24(8):1195-209. PubMed
2. Sellitti DF, Suzuki K. 2014. Thyroid 24(4):625. PubMed
3. Bellet D, et al. 1983. J. Clin. Endocrinol. Metab. 56:530. PubMed

Gene ID
7038 View all products for this Gene ID
UniProt
View information about Thyroglobulin on UniProt.org
Go To Top Version: 2    Revision Date: 11.30.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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