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FITC anti-human CD41 Antibody

Pricing & Availability
Clone
HIP8 (See other available formats)
Regulatory Status
RUO
Workshop
IV P38
Other Names
gpIIb, CD41a
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HIP8_FITC_062507
Human peripheral blood platelets stained with HIP8 FITC
  • HIP8_FITC_062507
    Human peripheral blood platelets stained with HIP8 FITC
Compare all formats See FITC spectral data
Cat # Size Price Quantity Check Availability Save
303703 25 tests 68€
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303704 100 tests 153€
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Description

CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Capuchin Monkey, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.

Application References
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. McCarty OJT, et al. 2000. Blood 96:1789.
  3. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  4. Zhi L et al. 2013. PLoS One. 8:e79869. (IHC)
Product Citations
  1. Wilkes MC, et al. 2022. Exp Hematol. 111:66. PubMed
  2. Karantanos T, et al. 2022. Haematologica. :. PubMed
  3. Jin J, et al. 2023. JCI Insight. 8:. PubMed
  4. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  5. Xu Y, et al. 2021. Stem Cell Res Ther. 12:112. PubMed
  6. Esteghamat F, et al. 2019. Nat Genet. 51:1233. PubMed
  7. Long A, et al. 2016. Toxicol Pathol. 44: 998 - 1012. PubMed
  8. Schmidt RA, et al. 2018. Transl Res. 195:1. PubMed
  9. Rolfes V, et al. 2018. Oncotarget. 9:27460. PubMed
  10. Di Buduo CA, et al. 2021. eLife. 10:00. PubMed
  11. Wang X, et al. 2018. Cell Death Dis. 9:578. PubMed
  12. Luni C, et al. 2011. Biotechnol Prog. 27:1154. PubMed
  13. Jain K, et al. 2019. EBioMedicine. 1.852777778. PubMed
  14. Damkham N, et al. 2022. Stem Cell Res Ther. 13:467. PubMed
  15. Wilkes MC, et al. 2020. Nat Commun. 2.780555556. PubMed
  16. Karantanos T, et al. 2022. Sci Adv. 8:eabl8952. PubMed
  17. Gleitz HFE, et al. 2021. STAR Protocols. 2(2):100538. PubMed
  18. Rai R, et al. 2020. Nat Commun. 4034:11. PubMed
  19. Headland S, et al. 2014. Sci Rep. 4:5237. PubMed
  20. Dinh HQ, et al. 2020. Immunity. 53(2):319-334.e6. PubMed
  21. Kawamoto E, et al. 2021. Biomedicines. 9:. PubMed
RRID
AB_314373 (BioLegend Cat. No. 303703)
AB_314373 (BioLegend Cat. No. 303704)

Antigen Details

Structure
Integrin family, α subunit of CD41/CD61 (GPIIb-IIIa) complex, 125/22 kD
Distribution

Platelets, megakaryocytes

Function
Platelet aggregation, platelet attachment to extracellular matrix
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Megakaryocytes, Platelets
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Denzin L, et al. 1996. J. Exp. Med. 184:2153.
2. Denzin L, et al. 1995. Cell 82:155.
3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.

Gene ID
3674 View all products for this Gene ID
UniProt
View information about CD41 on UniProt.org
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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