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PE anti-human CD267 (TACI) Antibody

Pricing & Availability
Clone
1A1 (See other available formats)
Regulatory Status
RUO
Other Names
TNFRSF13B, CD267, Transmembrane Activator and CAML Interactor (TACI)
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
1A1_PE_CD267_Antibody_1_090924
Human peripheral blood lymphocytes stained with CD19 PE/Cyanine5 and 1A1 PE
  • 1A1_PE_CD267_Antibody_1_090924
    Human peripheral blood lymphocytes stained with CD19 PE/Cyanine5 and 1A1 PE
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311906 100 tests 304 CHF
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Description

TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
TACI-transfected RBL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al.2004. J. Immunol. 173:807. (FC)
  2. Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed.
Product Citations
  1. Rossi M, et al. 2023. Elife. 12:. PubMed
  2. Lepse N, et al. 2016. Rheumatology. 55: 162 - 172. PubMed
  3. Meng L, et al. 2021. Front Oncol. 11:691705. PubMed
  4. Salazar-Camarena D, et al. 2016. Lupus. 25: 582 - 592. PubMed
  5. Tai YT, et al. 2019. Leukemia. 33:426. PubMed
  6. Flint S, et al. 2016. Haematologica. 101: 698 - 706. PubMed
RRID
AB_2203401 (BioLegend Cat. No. 311906)

Antigen Details

Structure
Type III transmembrane protein, TNF receptor superfamily, 32 kD
Distribution

B cells, meyloma cells

Function
Negative regulation of B cell function
Ligand/Receptor
BAFF/BLys, April, Syndecan-2
Cell Type
B cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Gross JA, et al. 2000. Nature 404:995.
2. Wu Y, et al. 2000. J. Biol Chem. 275:35478.
3. Yan M, et al. 2001. Nat. Immunol. 2:638.
4. Hymowitz A, et al. 2005. J. Biol. Chem. 280:7218.
5. Bischof D, et al. 2006. BLOOD 107:3235.

Gene ID
23495 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD267
Specificity Alt (DOES NOT SHOW ON TDS):
CD267
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD267 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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