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Purified anti-human CD201 (EPCR) Antibody

Pricing & Availability
Clone
RCR-401 (See other available formats)
Regulatory Status
RUO
Other Names
Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
RCR-401_PE_050411
HUVEC cells were stained with CD201 (clone RCR-401) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
  • RCR-401_PE_050411
    HUVEC cells were stained with CD201 (clone RCR-401) PE (filled histogram) or rat IgG1, κ PE isotype control (open histogram).
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351902 100 µg 141 CHF
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Description

Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, which results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_10895923 (BioLegend Cat. No. 351902)

Antigen Details

Structure
46 kD of N-glycosylated type I transmembrane protein
Distribution

Endothelial cells, subset of hematopoietic stem cells, subset of dendritic cells

Function
Inhibits blood coagulation, inflammation, and hematopoiesis
Interaction
Activated receptor1 (Par-1)
Ligand/Receptor
Protease C
Cell Type
Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Kerschen E, et al. 2010. J. Clin. Invest. 120:3167.
2. Iwasaki H, et al. 2010. Blood 116:544.
3. Balazs AB, et al. 2006. Blood 107:2317.

Gene ID
10544 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD201
Specificity Alt (DOES NOT SHOW ON TDS):
CD201
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD201 on UniProt.org
Go To Top Version: 2    Revision Date: 03.09.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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