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Purified anti-mouse CD26 (DPP-4) Antibody

Pricing & Availability
Clone
H194-112 (See other available formats)
Regulatory Status
RUO
Other Names
Dipeptidyl peptidase 4, THAM
Isotype
Rat IgG2a, κ
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Product Citations
publications
H194-112_PE_040910
C57BL/6 splenocytes stained with purified H194-112 conjugated with PE and CD3 (17A2) Alexa Fluor® 647
  • H194-112_PE_040910
    C57BL/6 splenocytes stained with purified H194-112 conjugated with PE and CD3 (17A2) Alexa Fluor® 647
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137801 50 µg 89 CHF
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137802 500 µg 405 CHF
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Description

CD26, also known as DPP IV or THAM, is a 220 kD type II transmembrane homodimer. It consists of an α/β hydrolase domain and an eight-blade beta-propeller domain.  After proteolysis of the membrane-bound CD26, a soluble form of DPP IV is released. CD26 is expressed on thymocytes (development dependent), T cells, B cells, NK cells, and macrophages. It is involved in T cell costimulation, endothelial cell migration and proteolysis processes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
BALB/c thymocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications include: in vitro activation of thymocytes1, immunoprecipitation from cell lysates and cell-free supernatants1,2 and immunohistochemical staining of frozen tissue sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Naquet P, et al. 1988. J. Immunol. 141:4101.
  2. Vivier I, et al. 1991. J. Immunol. 147:447.
  3. Sen A, et al. 2012. PNAS PubMed
  4. Coleman CM, et al. 2014. J Gen Virol. 95:408. PubMed
Product Citations
  1. Xu RH, et al. 2015. Immunity. 1148:43. PubMed
  2. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  3. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  4. Coleman C, et al. 2014. J Gen Virol. 95:408. PubMed
RRID
AB_10567106 (BioLegend Cat. No. 137801)
AB_10567106 (BioLegend Cat. No. 137802)

Antigen Details

Structure
Homodimer, each monomer is a single chain type II transmembranal molecule of 110 kD that consists of two domains; soluble form is released after proteolysis of the membrane form
Distribution

Mature thymocytes, activated T cells, B cells, NK cells, macrophages

Function
T cell costimulation, endothelial cell migration, proteolysis
Interaction
CAV1, IGF2R, PTPRC, BCL10, CARD1, IKBKB
Ligand/Receptor
ADA, collagen
Cell Type
B cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area
Immunology, Costimulatory Molecules
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Cooper KG, et al. 2009. Infect. Immun. 77:2447.
2. Eltzschig HK, et al. 2006. Blood 108:1602.
3. Peranteau WH, et al. 2006. Blood 108:4268.

Gene ID
13482 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD26
Specificity Alt (DOES NOT SHOW ON TDS):
CD26
App Abbreviation (DOES NOT SHOW ON TDS):
FC,IP,IHC-F
UniProt
View information about CD26 on UniProt.org
Go To Top Version: 2    Revision Date: 11.15.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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