- Clone
- S16007D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- P2Y12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
848001 | 25 µg | 112 CHF | ||||
848002 | 100 µg | 293 CHF |
Purinergic Receptor P2Y (P2RY12) is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2RY12 is not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. P2RY12 is a highly selective marker for microglia that specifically distinguishes these cells from other myeloid cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse P2RY12.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
FC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. For flow cytometric staining. a concentration range of 0.5 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research.
Learn more about the validation testing we performed on clone S16007D by watching our Scientific Poster Video. - Additional Product Notes
-
View more applications data for this product in our Scientific Poster Library.
- Product Citations
-
- RRID
-
AB_2650633 (BioLegend Cat. No. 848001)
AB_2650633 (BioLegend Cat. No. 848002)
Antigen Details
- Structure
- P2RY12 is a 347 amino acid protein with a molecular mass of 39.8 kD.
- Distribution
-
Tissue distribution: platelets, brain (microglia), lung, appendix, pituitary and adrenal glands.
Cellular distribution: cell membrane and cytosol. - Function
- G-protein coupled receptor that inhibits the adenylyl cyclase second messenger system.
- Ligand/Receptor
- ADP and ATP.
- Cell Type
- Microglia, Platelets
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- GPCR, Purinergic Receptors
- Antigen References
-
1. Orr AG, et al. 2009. Nat. Neurosci. 12(7):872-8.
- Gene ID
- 70839 View all products for this Gene ID
- Specificity (DOES NOT SHOW ON TDS):
- P2RY12
- Specificity Alt (DOES NOT SHOW ON TDS):
- P2RY12
- App Abbreviation (DOES NOT SHOW ON TDS):
- IHC-P,FC
- UniProt
- View information about P2RY12 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All P2RY12 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse P2RY12 | S16007D | IHC-P,FC |
PE anti-mouse P2RY12 | S16007D | FC |
APC anti-mouse P2RY12 | S16007D | FC |
Biotin anti-mouse P2RY12 | S16007D | IHC-P |
TotalSeq™-A0415 anti-mouse P2RY12 | S16007D | PG |
Spark YG™ 570 anti-mouse P2RY12 | S16007D | IHC-P |
APC/Fire™ 810 anti-mouse P2RY12 | S16007D | FC |
Alexa Fluor® 488 anti-mouse P2RY12 | S16007D | FC |
Alexa Fluor® 647 anti-mouse P2RY12 | S16007D | FC |
TotalSeq™-B0415 anti-mouse P2RY12 | S16007D | PG |
TotalSeq™-C0415 anti-mouse P2RY12 | S16007D | PG |
APC/Cyanine7 anti-mouse P2RY12 | S16007D | FC |
PE/Cyanine7 anti-mouse P2RY12 | S16007D | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse P2RY12
IHC staining of purified anti-P2RY12 antibody (clone S16007D... IHC staining of purified anti-P2RY12 antibody (clone S16007D... IHC staining of purified anti-P2RY12 antibody (clone S16007D... Single cell suspension of mouse brain tissue was stained wit... -
PE anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
APC anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
Biotin anti-mouse P2RY12
IHC staining of Biotin anti-P2RY12 antibody (clone S16007D) ... IHC staining of Biotin anti-P2RY12 antibody (clone S16007D) ... -
TotalSeq™-A0415 anti-mouse P2RY12
-
Spark YG™ 570 anti-mouse P2RY12
IHC staining of Spark YG™ 570 anti-P2RY12 antibody (clone S1... -
APC/Fire™ 810 anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
Alexa Fluor® 488 anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
Alexa Fluor® 647 anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
TotalSeq™-B0415 anti-mouse P2RY12
-
TotalSeq™-C0415 anti-mouse P2RY12
-
APC/Cyanine7 anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges... -
PE/Cyanine7 anti-mouse P2RY12
C57BL/6 mouse microglia were enriched from collagenase-diges...
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