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APC anti-human CD107a (LAMP-1) Antibody

Pricing & Availability
Clone
W18263B (See other available formats)
Regulatory Status
RUO
Other Names
Lysosome-Associated Membrane Protein 1, LAMP-1, LGP-120
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
W18263B_APC_CD107a_Antibody_022422
Thrombin-activated human peripheral blood platelets were stained with anti-human CD107a (LAMP1) (clone W18263B) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram).
  • W18263B_APC_CD107a_Antibody_022422
    Thrombin-activated human peripheral blood platelets were stained with anti-human CD107a (LAMP1) (clone W18263B) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram).
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301103 25 tests 142 CHF
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301104 100 tests 305 CHF
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Description

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
RBL1 transfectant (full length)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2910376 (BioLegend Cat. No. 301103)
AB_2910376 (BioLegend Cat. No. 301104)

Antigen Details

Structure
CD107a is expressed by macrophages, epithelial cells, endothelial cells, some tumor cells; located on the luminal side of lysosomes or on the surface of cell membranes
Distribution

CD107a is expressed by macrophages, epithelial cells, endothelial cells, some tumor cells; located on the luminal side of lysosomes or on the surface of cell membranes

Function
Protect lysosomal membrane from lysosomal hydrolases, adhesion
Ligand/Receptor
Galaptin
Antigen References
  1. Sarafian V, et al. 2006. Arch Dermatol Res. 298:7381.
  2. Schlossman SF, et al. 1995. Leukocyte Typing V:White Cell Differentiation Antigens. New York:Oxford University Press.
  3. Sawada R, et al. 1993. J Biol Chem. 268:12675.
  4. Chen JW, et al. 1988. J Biol Chem. 263:8754.
  5.  Chen JW, et al. 1986. Biochem Soc Symp. 51:97112.
Gene ID
3916 View all products for this Gene ID
UniProt
View information about CD107a on UniProt.org
Go To Top Version: 1    Revision Date: 02.24.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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