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APC anti-human CD142 Antibody

Pricing & Availability
Clone
NY2 (See other available formats)
Regulatory Status
RUO
Other Names
Coagulation Factor III, Tissue Factor (TF), Thromboplastin, platelet tissue factor, factor III, factor 3, F3, F-3, TFA
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
NY2_APC_CD142_Antibody_FC_121114
LPS-stimulated human monocytes were stained with CD142 (clone NY2) APC (filled histogram), or mouse IgG1, κ APC isotype control (open histogram).
  • NY2_APC_CD142_Antibody_FC_121114
    LPS-stimulated human monocytes were stained with CD142 (clone NY2) APC (filled histogram), or mouse IgG1, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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365205 25 tests 113 CHF
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365206 100 tests 279 CHF
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Description

CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Rosas M, et al. 2020. PLoS One. 15:e0240189. PubMed
  2. Jin J, et al. 2023. JCI Insight. 8:. PubMed
  3. Manukyan G, et al. 2020. Auto Immun Highlights. 11:5. PubMed
  4. Aldeghaither DS, et al. 2019. Cancer Immunol Res. 7:230. PubMed
  5. Balbi C, et al. 2021. EBioMedicine. 67:103369. PubMed
RRID
AB_2564567 (BioLegend Cat. No. 365205)
AB_2564567 (BioLegend Cat. No. 365206)

Antigen Details

Structure
45 kD Type I transmembrane glycoprotein.
Distribution

Smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells, astrocytes, myocardium, liver stromal cells, pancreas cell, stimulated endothelial cells, stimulated monocytes

Function
Blood coagulation
Ligand/Receptor
Coagulation Factor VII
Cell Type
Astrocytes, Endothelial cells, Epithelial cells, Fibroblasts
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Carson SD, et al. 1994. Blood 84:526.
2. McComb RD, et al. 1991. Am. J. Pathol. 139:491.
3. Whittle SM, et al. 1995. Thromb. Res. 79:451.

Gene ID
2152 View all products for this Gene ID
UniProt
View information about CD142 on UniProt.org
Go To Top Version: 1    Revision Date: 12.16.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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