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APC anti-human CXCR7 Antibody

Pricing & Availability
Clone
10D1-J16 (See other available formats)
Regulatory Status
RUO
Other Names
Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3
Isotype
Mouse IgG2a, κ
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Product Citations
publications
10D1-J16_APC_CXCR7_Antibody_FC_051115
CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 10D1-J16) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • 10D1-J16_APC_CXCR7_Antibody_FC_051115
    CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 10D1-J16) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
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391405 25 tests 172 CHF
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391406 100 tests 385 CHF
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Description

CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Zhang X, et al. 2021. Oncogene. 40:1516. PubMed
RRID
AB_2565682 (BioLegend Cat. No. 391405)
AB_2565682 (BioLegend Cat. No. 391406)

Antigen Details

Structure
G Protein-Coupled Receptor super family
Distribution

Monocytes, B cells, T cells, and mature dendritic cells.

Function
Regulates trafficking and activation of leukocytes.
Ligand/Receptor
CXCL12/SDF-1 and CXCL11/I-TAC.
Cell Type
B cells, Dendritic cells, Monocytes, T cells
Biology Area
Cell Biology, Immunology, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Torossian F, et al. 2014. Blood 123:191.
2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629.
3. Yates TJ, et al. 2013. Cancer 119:61.
4. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
5. Infantino S, et al. 2006. J. Immunol. 176:2197.

Gene ID
57007 View all products for this Gene ID
UniProt
View information about CXCR7 on UniProt.org
Go To Top Version: 1    Revision Date: 05.12.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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