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- Clone
- T49-25 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Ephrin Type-B Receptor 6, Eph receptor B6, tyrosine-protein kinase-defective receptor B6
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human EPHB6 (clone T49-25) APC (left) or mouse IgG1, κ APC isotype control (right). Cells were costained with anti-human CD3 PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 384305 | 25 tests | 196 CHF | ||||
| 384306 | 100 tests | 409 CHF | ||||
EPHB6 is a 110 kD protein transmembrane protein of the ephrin receptor family of tyrosine kinases, but lacks kinase activity. It is expressed on skin keratinocytes, neurons, thymocytes, immature T Cells, and a small population of peripheral CD4+ T Cells and CD8+ T Cells. Loss of EPHB6 expression has been related with increased metastatic melanoma and neuroblastoma, suggesting a role in suppressing tumorigenicity.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- GST-fusion extracellular domain region 3 of human EPHB6 recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- RRID
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AB_3068073 (BioLegend Cat. No. 384305)
AB_3068073 (BioLegend Cat. No. 384306)
Antigen Details
- Structure
- 110 kD transmembrane protein, tyrosine kinase
- Distribution
-
T lymphocytes, thymocytes, neurons, keratinocytes
- Ligand/Receptor
- Ephrin B6, Ephrin B2, Ephrin B1
- Cell Type
- Neurons, T cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Neuroscience
- Antigen References
-
- Matsuoka H, et al. 2005. J Biol Chem. 280:29355-63
- Strozen T, et al. 2021. Int J Mol Sci. 22:821
- Zhou R. 1998. Pharm Ther. 77:151-81
- Gene ID
- 2051 View all products for this Gene ID
- UniProt
- View information about EPHB6 on UniProt.org
Related FAQs
Other Formats
View All EPHB6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human EPHB6 | T49-25 | FC |
| PE anti-human EPHB6 | T49-25 | FC |
| APC anti-human EPHB6 | T49-25 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human EPHB6
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human EPHB6
Human peripheral blood lymphocytes were stained with anti-hu... -
APC anti-human EPHB6
Human peripheral blood lymphocytes were stained with anti-hu...
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