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APC anti-mouse CD265 (RANK) Antibody

Pricing & Availability
Clone
R12-31 (See other available formats)
Regulatory Status
RUO
Other Names
Receptor activator of NF-κB, tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), osteoclast differentiation factor receptor (ODFR), CD265
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
R12-31_APC_CD265_RANK_Antibody_042921.png
Mouse RANK transfected cells were stained with anti-mouse CD265 (RANK) (clone R12-31) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • R12-31_APC_CD265_RANK_Antibody_042921.png
    Mouse RANK transfected cells were stained with anti-mouse CD265 (RANK) (clone R12-31) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
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119807 25 µg 107 CHF
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119808 100 µg 296 CHF
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Description

CD265 is a type I transmembrane protein also known as receptor activator of NF-κB (RANK), tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), and osteoclast differentiation factor receptor (ODFR). RANK is a receptor for RANK ligand/TRANCE/OPGL and is involved in osteoclastogenesis and T cell/dendritic cell interactions. RANK is ubiquitously expressed in trabecular bone, thymus, small intestine, lung, brain, and kidney.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Hildebrand D, et al. 2010. Infect. Immun. 79:220. PubMed
RRID
AB_2892276 (BioLegend Cat. No. 119807)
AB_2892276 (BioLegend Cat. No. 119808)

Antigen Details

Structure
TNF superfamily member, Type I membrane protein
Distribution

Ubiquitous expression; highest levels in trabecular bone, thymus, small intestine, lung, brain, and kidney. Weakly expressed in spleen and bone marrow.

Function
Essential for RANK ligand mediated osteoclastogenesis. Involved in the interactions between T cells and dendritic cells
Interaction
Cytoplasmic domain interacts with TRAF2, TRAF5, and TRAF6
Ligand/Receptor
Receptor for RANK ligand/TRANCE/OPGL
Biology Area
Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Anderson DM, et al. 1997. Nature. 390:175.
  2. Nakagawa N, et al. 1998. Biochem Biophys Res Commun. 253:395.
  3. Ha J, et al. 2010. J Immunol. 184:4717.
Gene ID
21934 View all products for this Gene ID
UniProt
View information about CD265 on UniProt.org
Go To Top Version: 1    Revision Date: 04.29.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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