- Clone
- R12-31 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Receptor activator of NF-κB, tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), osteoclast differentiation factor receptor (ODFR), CD265
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
119807 | 25 µg | 107 CHF | ||||
119808 | 100 µg | 296 CHF |
CD265 is a type I transmembrane protein also known as receptor activator of NF-κB (RANK), tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), and osteoclast differentiation factor receptor (ODFR). RANK is a receptor for RANK ligand/TRANCE/OPGL and is involved in osteoclastogenesis and T cell/dendritic cell interactions. RANK is ubiquitously expressed in trabecular bone, thymus, small intestine, lung, brain, and kidney.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Hildebrand D, et al. 2010. Infect. Immun. 79:220. PubMed
- RRID
-
AB_2892276 (BioLegend Cat. No. 119807)
AB_2892276 (BioLegend Cat. No. 119808)
Antigen Details
- Structure
- TNF superfamily member, Type I membrane protein
- Distribution
-
Ubiquitous expression; highest levels in trabecular bone, thymus, small intestine, lung, brain, and kidney. Weakly expressed in spleen and bone marrow.
- Function
- Essential for RANK ligand mediated osteoclastogenesis. Involved in the interactions between T cells and dendritic cells
- Interaction
- Cytoplasmic domain interacts with TRAF2, TRAF5, and TRAF6
- Ligand/Receptor
- Receptor for RANK ligand/TRANCE/OPGL
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Anderson DM, et al. 1997. Nature. 390:175.
- Nakagawa N, et al. 1998. Biochem Biophys Res Commun. 253:395.
- Ha J, et al. 2010. J Immunol. 184:4717.
- Gene ID
- 21934 View all products for this Gene ID
- UniProt
- View information about CD265 on UniProt.org
Related FAQs
Other Formats
View All CD265 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Biotin anti-mouse CD265 (RANK) | R12-31 | FC |
PE anti-mouse CD265 (RANK) | R12-31 | FC |
APC anti-mouse CD265 (RANK) | R12-31 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Biotin anti-mouse CD265 (RANK)
Mouse RANK transfected cells stained with biotinylated R12-3... -
PE anti-mouse CD265 (RANK)
Mouse RANK transfected cells stained with R12-31 PE -
APC anti-mouse CD265 (RANK)
Mouse RANK transfected cells were stained with anti-mouse CD...
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