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APC anti-mouse/human CD44 Recombinant Antibody

Pricing & Availability
Clone
QA19A43 (See other available formats)
Regulatory Status
RUO
Other Names
Hermes, Pgp1, H-CAM, or HUTCH
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
QA19A43_APC_CD44_RECOM_Antibody_090121.png
C57BL/6 splenocytes were stained with anti-mouse/human CD44 recombinant (clone QA19A43) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • QA19A43_APC_CD44_RECOM_Antibody_090121.png
    C57BL/6 splenocytes were stained with anti-mouse/human CD44 recombinant (clone QA19A43) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
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163603 25 µg 149 CHF
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163604 100 µg 350 CHF
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Description

CD44 is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Recombinant
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2894633 (BioLegend Cat. No. 163603)
AB_2894633 (BioLegend Cat. No. 163604)

Antigen Details

Structure
Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD
Distribution

All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells.

Function
Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM.
Ligand/Receptor
Hyaluronan, MIP-1β, fibronectin, collagen.
Antigen References
  1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
  2. Haynes BF, et al. 1991. Cancer Cells. 3:347.
  3. Goldstein LA, et al. 1989. Cell. 56:1063.
  4. Mikecz K, et al. 1995. Nat Med. 1:558.
  5. Hegde V, et al. 2008. J Leukocyte Biol. 84:134.
  6. Liu T, et al. 2009. Biol Direct. 4:40.
Gene ID
12505 View all products for this Gene ID
UniProt
View information about CD44 on UniProt.org
Go To Top Version: 1    Revision Date: 09.01.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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