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APC/Fire™ 810 anti-mouse CD95 (Fas) Antibody

Pricing & Availability
Clone
SA367H8 (See other available formats)
Regulatory Status
RUO
Other Names
Fas, ALPS1A, APO-1, APT1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SA367H8_APC-FIRE-810_CD95_Antibody_111822
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 FITC and anti-mouse CD95 (Fas) (clone SA367H8) APC/Fire™ 810 (left) or mouse IgG1, κ APC/Fire™ 810 isotype control (right).
  • SA367H8_APC-FIRE-810_CD95_Antibody_111822
    C57BL/6 mouse splenocytes were stained with anti-mouse CD3 FITC and anti-mouse CD95 (Fas) (clone SA367H8) APC/Fire™ 810 (left) or mouse IgG1, κ APC/Fire™ 810 isotype control (right).
Compare all formats See APC/Fire™ 810 spectral data
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152623 25 µg 155 CHF
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152624 100 µg 347 CHF
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Description

CD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as  thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induce apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintining peripheral tolerance of the immune system.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse Fas Transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 810 under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* APC/Fire™ 810 has a maximum excitation of 650 nm and a maximum emission of 810 nm.


Excessive exposure to light, and commonly used fixation, permeabilization buffers can affect APC/Fire™ 810 fluorescence signal intensity and spread. Please keep conjugates protected from light exposure. For more information and representative data, visit our Fire Dyes page.
Excitation Laser
Red Laser (633 nm)
RRID
AB_2927996 (BioLegend Cat. No. 152623)
AB_2927996 (BioLegend Cat. No. 152624)

Antigen Details

Structure
CD95 (Fas) is an approximately 45 kD type I transmembrane protein; cystiene-rich domain, death domain.
Distribution

Thymus, spleen, liver, heart, lung, and ovary.

Function
Induction of apoptosis.
Interaction
Caspase 8, caspase 10, CFLAR, FADD, PDCD6, SUMO1, and TNFRSF6.
Ligand/Receptor
FasL
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Ogasawara J, et al. 1995. J Exp Med. 181:485-91.
  2. Ogasawara J, et al. 1993. Nature. 364:806-9.
  3. Nishimura Y, et al. 1995. J Immunol. 154:4395-403.
Gene ID
14102 View all products for this Gene ID
UniProt
View information about CD95 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.18.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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