- Clone
- UV4 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-6R1, gp80, IL-6 receptor alpha, IL-6R
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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352808 | 100 µg | 229 CHF |
CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human myeloma cell line U266
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.
-
Application References
(PubMed link indicates BioLegend citation) -
- Huang YW and Vitetta ES. 1993. Hybridoma 12:621.
- RRID
-
AB_11203528 (BioLegend Cat. No. 352808)
Antigen Details
- Structure
- Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD
- Distribution
-
Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts
- Function
- Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation
- Interaction
- CD130, c-Src, STAT3, WWP1, WWP2
- Ligand/Receptor
- IL-6
- Cell Type
- B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797.
2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London.
3. Boulanger MJ, et al. 2003. Science 300:2101.
4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820. - Gene ID
- 3570 View all products for this Gene ID
- UniProt
- View information about CD126 on UniProt.org
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other Formats
View All CD126 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
APC anti-human CD126 (IL-6Rα) | UV4 | FC |
PE anti-human CD126 (IL-6Rα) | UV4 | FC |
Biotin anti-human CD126 (IL-6Rα) | UV4 | FC |
Purified anti-human CD126 (IL-6Rα) | UV4 | FC |
PerCP/Cyanine5.5 anti-human CD126 (IL-6Rα) | UV4 | FC |
PE/Cyanine7 anti-human CD126 (IL-6Rα) | UV4 | FC |
TotalSeq™-A0819 anti-human CD126 (IL-6Rα) | UV4 | PG |
TotalSeq™-C0819 anti-human CD126 (IL-6Rα) | UV4 | PG |
TotalSeq™-B0819 anti-human CD126 (IL-6Rα) Antibody | UV4 | PG |
TotalSeq™-D0819 anti-human CD126 (IL-6Rα) Antibody | UV4 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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APC anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with CD3 PE ... -
PE anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with CD3 APC... -
Biotin anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with CD3 APC... -
Purified anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with purifie... -
PerCP/Cyanine5.5 anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with CD3 APC... -
PE/Cyanine7 anti-human CD126 (IL-6Rα)
Human peripheral blood lymphocytes were stained with CD3 APC... -
TotalSeq™-A0819 anti-human CD126 (IL-6Rα)
-
TotalSeq™-C0819 anti-human CD126 (IL-6Rα)
-
TotalSeq™-B0819 anti-human CD126 (IL-6Rα) Antibody
-
TotalSeq™-D0819 anti-human CD126 (IL-6Rα) Antibody
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