Biotin anti-human CD303 BDCA-2 Antibody anti-CD303

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Clone: 201A (See other available formats)
Regulatory Status: RUO
Other Names: CLEC4C, CLECSF11, CLECSF7, DLEC, HECL
Isotype: Mouse IgG2a, κ
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Product Citations: publications

201A_Biotin_CD303_Antibody_1_032316 — Human peripheral mononuclear cells were stained with CD123 APC and biotinylated CD303 (clone 201A) (top), or biotinylated mouse IgG2a, κ isotype control (bottom), followed by SAV-PE. Data shown was gated on the lymphocyte and monocyte populations.

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354220

100 µg

265 CHF

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Description

CD303, also known as BDCA-2 and CLEC4C, is a 38 kD type II transmembrane glycoprotein. It is a member of the C-type lectin superfamily. CD303 is expressed by plasmacytoid dendritic cells (pDCs) and is involved in cell adhesion, signaling, and antigen capture and processing. Crosslinking of CD303 inhibits the production of IFN-α/β and TLR-9 induced pDCs maturation.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2572077 (BioLegend Cat. No. 354220)

Antigen Details

Structure: Type II transmembrane protein, 38 kD, member of the C-type lectin superfamily
Distribution: Plasmacytoid dendritic cells
Function: Antigen capture, inhibition of IFN α/β production
Cell Type: Dendritic cells
Biology Area: Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Jähn PS, et al. 2010. Cell Immunol. 265:15.
2. Graham LM and Brown GD. 2009. Cytokine 48:148.
3. Röck J, et al. 2007. Eur. J. Immunol. 37:3564.
4. Dzionek A, et al. 2001. J. Exp. Med. 194:1823.
Gene ID: 170482 View all products for this Gene ID
UniProt: View information about CD303 on UniProt.org

Documentation

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Description	Clone	Applications

Related Pages & Pathways

Pathways

Related FAQs

How many biotin molecules are per antibody structure?: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.

Other Formats

View All CD303 Reagents Request Custom Conjugation

Description	Clone	Applications
APC anti-human CD303 (BDCA-2)	201A	FC
Purified anti-human CD303 (BDCA-2)	201A	FC
PE anti-human CD303 (BDCA-2)	201A	FC
FITC anti-human CD303 (BDCA-2)	201A	FC
PerCP/Cyanine5.5 anti-human CD303 (BDCA-2)	201A	FC
Brilliant Violet 421™ anti-human CD303 (BDCA-2)	201A	FC
PE/Cyanine7 anti-human CD303 (BDCA-2)	201A	FC
Purified anti-human CD303 (BDCA-2) (Maxpar® Ready)	201A	FC,CyTOF®
Alexa Fluor® 647 anti-human CD303 (BDCA-2)	201A	FC
Biotin anti-human CD303 (BDCA-2)	201A	FC
Brilliant Violet 785™ anti-human CD303 (BDCA-2)	201A	FC
Brilliant Violet 605™ anti-human CD303 (BDCA-2)	201A	FC
PE/Dazzle™ 594 anti-human CD303 (BDCA-2)	201A	FC
Alexa Fluor® 700 anti-human CD303 (BDCA-2)	201A	FC
Alexa Fluor® 488 anti-human CD303 (BDCA-2)	201A	FC
Brilliant Violet 510™ anti-human CD303 (BDCA-2)	201A	FC
Brilliant Violet 711™ anti-human CD303 (BDCA-2)	201A	FC
APC/Fire™ 750 anti-human CD303 (BDCA-2)	201A	FC
APC/Cyanine7 anti-human CD303 (BDCA-2)	201A	FC
TotalSeq™-A0370 anti-human CD303 (BDCA-2)	201A	PG
TotalSeq™-C0370 anti-human CD303 (BDCA-2)	201A	PG
TotalSeq™-B0370 anti-human CD303 (BDCA-2)	201A	PG
TotalSeq™-D0370 anti-human CD303 (BDCA-2)	201A	PG
Spark Blue™ 550 anti-human CD303 (BDCA-2) (Flexi-Fluor™)	201A	FC
Spark Red™ 718 anti-human CD303 (BDCA-2) (Flexi-Fluor™)	201A	FC
APC/Fire™ 810 anti-human CD303 (BDCA-2)	201A	FC
Spark Violet™ 538 anti-human CD303 (BDCA-2)	201A	FC
PerCP/Fire™ 806 anti-human CD303 (BDCA-2)	201A	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 03.24.2016

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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