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Brilliant Violet 421™ anti-human CD198 (CCR8) Antibody

Pricing & Availability
Clone
S19016H (See other available formats)
Regulatory Status
RUO
Other Names
CC-CKR-8, C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
S19016H_BV421_CD198_Antibody_122723
Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD198 (CCR8) (clone S19016H) Brilliant Violet 421™ (left), or rat IgG2b, κ Brilliant Violet 421™ isotype control (right).
  • S19016H_BV421_CD198_Antibody_122723
    Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD198 (CCR8) (clone S19016H) Brilliant Violet 421™ (left), or rat IgG2b, κ Brilliant Violet 421™ isotype control (right).
Compare all formats See Brilliant Violet 421™ spectral data
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365813 25 tests 190 CHF
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365814 100 tests 395 CHF
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Description

CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CCR8-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Clone S19016H induces complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) on CCR8-transfected cells.

RRID
AB_3097394 (BioLegend Cat. No. 365813)
AB_3097394 (BioLegend Cat. No. 365814)

Antigen Details

Structure
Seven hydrophobic transmembrane domains
Distribution

Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons

Cell Type
Tregs
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Tiffany HL, et al. 1997. J Exp Med. 186:165-70.
  2. Goya I, et al. 1998. J Immunol. 160:1975-81.
  3. Lee S, et al. 2000. J Virol. 74:6946-52.
  4. Chensue SW, et al. 2001. J Exp Med. 193:573-84.
  5. Qu C, et al. 2004. J Exp Med. 200:1231-41.
  6. Isolam SA, et al. 2013. J Exp Med. 210:1889-98.
Gene ID
1237 View all products for this Gene ID
UniProt
View information about CD198 on UniProt.org

Related FAQs

What is the F/P ratio range of our BV421™ format antibody reagents?

It is lot-specific. On average it ranges between 2-4.

Go To Top Version: 1    Revision Date: 12.27.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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