- Clone
- 11C1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
316931 | 25 tests | 190 CHF | ||||
316932 | 100 tests | 435 CHF |
B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- BAFF-R-L1.2 transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC)
- Personal communication. (Block)
- RRID
-
AB_3083307 (BioLegend Cat. No. 316931)
AB_3083307 (BioLegend Cat. No. 316932)
Antigen Details
- Structure
- Type III transmembrane protein, TNF receptor superfamily, 19 kD
- Distribution
-
Mature B cells, B cell lymphoma, T cell subset
- Function
- Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation
- Ligand/Receptor
- BAFF/BLys, associate with TRAF3
- Cell Type
- B cells, Leukemia, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Thompson JS, et al. 2001. Science 293:2108.
2. Ng LG, et al.2004. J. Immunol. 173:807.
3. Rodig SJ, et al. 2005. Human Pathol. 36:1113.
4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750.
5. Kayagaki N, et al. 2002 Immunity 17:515. - Gene ID
- 115650 View all products for this Gene ID
- UniProt
- View information about CD268 on UniProt.org
Related FAQs
- What is the F/P ratio range of our BV421™ format antibody reagents?
-
It is lot-specific. On average it ranges between 2-4.
Other Formats
View All CD268 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD268 (BAFF-R) | 11C1 | FC,IHC-P |
FITC anti-human CD268 (BAFF-R) | 11C1 | FC |
PE anti-human CD268 (BAFF-R) | 11C1 | FC |
APC/Cyanine7 anti-human CD268 (BAFF-R) | 11C1 | FC |
Alexa Fluor® 647 anti-human CD268 (BAFF-R, BAFFR) | 11C1 | FC |
APC anti-human CD268 (BAFF-R, BAFFR) | 11C1 | FC |
PerCP/Cyanine5.5 anti-human CD268 (BAFF-R) | 11C1 | FC |
PE/Cyanine7 anti-human CD268 (BAFF-R) | 11C1 | FC |
PE/Dazzle™ 594 anti-human CD268 (BAFF-R) | 11C1 | FC |
Biotin anti-human CD268 (BAFF-R) | 11C1 | FC |
TotalSeq™-A0215 anti-human CD268 (BAFF-R) | 11C1 | PG |
TotalSeq™-C0215 anti-human CD268 (BAFF-R) | 11C1 | PG |
TotalSeq™-B0215 anti-human CD268 (BAFF-R) | 11C1 | PG |
Brilliant Violet 421™ anti-human CD268 (BAFF-R) | 11C1 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes stained with purified11C1... Human paraffin-embedded tonsil tissue slices were prepared w... -
FITC anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes stained with 11C1 FITC -
PE anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes stained with CD19 FITC an... -
APC/Cyanine7 anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes were stained with CD19 FI... -
Alexa Fluor® 647 anti-human CD268 (BAFF-R, BAFFR)
Human peripheral blood lymphocytes stained with 11C1 Alexa F... -
APC anti-human CD268 (BAFF-R, BAFFR)
Human peripheral blood lymphocytes stained with CD19 (HIB19)... -
PerCP/Cyanine5.5 anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes were stained with CD19 AP... -
PE/Cyanine7 anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes were stained with CD19 AP... -
PE/Dazzle™ 594 anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes were stained with CD19 AP... -
Biotin anti-human CD268 (BAFF-R)
Human peripheral blood lymphocytes were stained with Brillia... -
TotalSeq™-A0215 anti-human CD268 (BAFF-R)
-
TotalSeq™-C0215 anti-human CD268 (BAFF-R)
-
TotalSeq™-B0215 anti-human CD268 (BAFF-R)
-
Brilliant Violet 421™ anti-human CD268 (BAFF-R)
Human peripheral blood cells were surface stained with anti-...
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