- Clone
- 2A2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Receptor tyrosine kinase-like orphan receptor 1, Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase receptor-related 1, NTRKR1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
357811 | 25 tests | 215 CHF | ||||
357812 | 100 tests | 435 CHF |
ROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.
Product DetailsProduct Details
- Isotype Control
- Brilliant Violet 711™ Mouse IgG1, κ Isotype Ctrl
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- Application Notes
-
Clone 2A2 binds to the membrane distal Ig-domain of ROR1. Clone 2A2 has also been shown to exhibit cross reactivity towards mouse ROR12.
-
Application References
(PubMed link indicates BioLegend citation) -
- Dave H, et al. 2012. PLoS One 7:e52655. (FC)
- Baskar S, et al. 2012. MAbs. 4:349. (FC)
- RRID
-
AB_2687389 (BioLegend Cat. No. 357811)
AB_2687389 (BioLegend Cat. No. 357812)
Antigen Details
- Structure
- Type I transmembrane protein, consist of 1 frizzled domain, 1 Ig-like C2-type domain, 1 kringle domain, and 1 non-functional kinase domain; member of the ROR subfamily of surface receptors
- Distribution
-
Embryonic tissue, central nervous system, chronic lymphocytic leukemia cells
- Ligand/Receptor
- Wnt5a
- Cell Type
- Embryonic Stem Cells, Leukemia
- Biology Area
- Immunology, Stem Cells
- Antigen References
-
- Bicocca VT, et al. 2012. Cancer Cell. 22:656.
- Zhang S, et al. 2012. PLoS One 7:e31127.
- Uhrmacher S, et al. 2011. Leuk Res. 35:1360.
- Yang J, et al. 2011. PLoS One 6:e21018.
- Grumolato L, et al. 2010. Genes Dev. 24:2517.
- Gene ID
- 4919 View all products for this Gene ID
- UniProt
- View information about ROR1 on UniProt.org
Related Products
Description | Clone | Applications |
---|---|---|
Cell Staining Buffer | FC,ICC,ICFC | |
RBC Lysis Buffer (10X) | FC | |
Human TruStain FcX™ (Fc Receptor Blocking Solution) | FC,ICC,ICFC | |
Brilliant Violet 711™ Mouse IgG1, κ Isotype Ctrl | MOPC-21 | FC,ICFC |
Lymphopure™ | Cell Sep - Pos,Cell Sep - Neg | |
Compensation Beads | FC |
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All ROR1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE/Cyanine7 anti-human ROR1 | 2A2 | FC |
Purified anti-human ROR1 | 2A2 | FC |
PE anti-human ROR1 | 2A2 | FC |
APC anti-human ROR1 | 2A2 | FC |
PerCP/Cyanine5.5 anti-human ROR1 | 2A2 | FC |
Brilliant Violet 711™ anti-human ROR1 | 2A2 | FC |
Brilliant Violet 421™ anti-human ROR1 | 2A2 | FC |
APC/Fire™ 750 anti-human ROR1 | 2A2 | FC |
Biotin anti-human ROR1 | 2A2 | FC |
PE/Dazzle™ 594 anti-human ROR1 | 2A2 | FC |
Alexa Fluor® 647 anti-human ROR1 | 2A2 | FC |
TotalSeq™-A1044 anti-human ROR1 | 2A2 | PG |
TotalSeq™-B1044 anti-human ROR1 | 2A2 | PG |
TotalSeq™-C1044 anti-human ROR1 | 2A2 | PG |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE/Cyanine7 anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
Purified anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with purif... -
PE anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
APC anti-human ROR1
NCCIT cells were stained with ROR1 (clone 2A2) APC (filled h... -
PerCP/Cyanine5.5 anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
Brilliant Violet 711™ anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
Brilliant Violet 421™ anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
APC/Fire™ 750 anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
Biotin anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with Bioti... -
PE/Dazzle™ 594 anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
Alexa Fluor® 647 anti-human ROR1
Human teratocarcinoma cell line NCCIT was stained with ROR1 ... -
TotalSeq™-A1044 anti-human ROR1
-
TotalSeq™-B1044 anti-human ROR1
-
TotalSeq™-C1044 anti-human ROR1
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