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PE anti-human CD222 (IGF2R) Recombinant Antibody

Pricing & Availability
Clone
QA19A18 (See other available formats)
Regulatory Status
RUO
Other Names
CD222, Insulin-like growth factor 2 Receptor (IGF2R), Cation-independent mannose 6-phosphate receptor (CIMPR), or Mannose-6 phosphate receptor (M6PR)
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA19A18_PE_CD222_RECOM_Antibody_110521
Human peripheral blood mononuclear cells were fixed, permeabilized, and then intracellularly stained with anti-human CD222 recombinant PE (clone QA19A18) (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • QA19A18_PE_CD222_RECOM_Antibody_110521
    Human peripheral blood mononuclear cells were fixed, permeabilized, and then intracellularly stained with anti-human CD222 recombinant PE (clone QA19A18) (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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364203 25 tests 98 CHF
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364204 100 tests 226 CHF
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Description

QA19A18 recombinant antibody binds to CD222 in human, which is also known as the Insulin-like growth factor 2 receptor (IGF2R), cation-independent mannose-6-phosphate receptor (CIMPR), and mannose-6 phosphate receptor (M6PR). CD222 is a type I transmembrane glycoprotein present largely intracellularly in the Golgi apparatus and endosomal compartments, but also at the cell surface. CD222 is expressed ubiquitously in a vast majority of higher eukaryotic cell types and the central component of endosomal transport pathways. The variety of CD222 ligands implicates that CD222 plays important functions in many pathological processes, such as biogenesis of lysosomes, regulation of IGF2, LTGFβ activation, etc. Loss of CD222 is associated with inhibition of T effector cell function.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC, FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2904388 (BioLegend Cat. No. 364203)
AB_2904388 (BioLegend Cat. No. 364204)

Antigen Details

Structure
Type I transmembrane glycoprotein
Distribution

Ubiquitously expressed on many cell types (Monocytes/Granulocytes)

Function
Biogenesis of lysosomes, embryogenesis, cell migration
Interaction
DPP4, heterotrimeric retromer cargo-selection complex (CSC)
Ligand/Receptor
Insulin-like growth factors, latent TGF-β, leukemia inhibitory factor (LIF), proliferin, prorenin, plasminogen
Molecular Family
Growth Factors
Antigen References
  1. Leksa V, et al. 2017. Immunol Lett. 190:194.
  2. Pfisterer K, et al. 2014. J Immunol. 193:2718.
  3. Wood R, et al. 2008. J Biol Chem. 
Gene ID
3482 View all products for this Gene ID
UniProt
View information about CD222 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.05.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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