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- Clone
- UP-D2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD300LF, IREM-1, IgSF13,
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes stained with UP-D2 PE
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 340604 | 100 tests | 360 CHF | ||||
IREM-1 (immune receptor expressed by myeloid cell 1) is a type I single transmembrane protein encoded by human chromosome 17q24.25. A member of the CD300 (CMRF-35) family and the Ig superfamily, IREM-1 is also known as CD300F, or CD300LF (CD300-like member F). CD300F is expressed on monocytes, granulocytes, and myeloid leukemia cell lines. The cytoplasmic domain of IREM-1 contains an ITIM and associates with the P85α subunit of PI3K (phosphoinositide 3-kinase). IREM-1 also functions as an inhibitory receptor.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Additional reported applications include: Coengagement of IREM-1 with UP-D2 inhibits FcReI-mediated degranulation, immunoprecipitation
-
Application References
(PubMed link indicates BioLegend citation) -
- Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690
- Lee SM, et al. 2011. J. Immunol. 186:6296. PubMed.
- RRID
-
AB_2074121 (BioLegend Cat. No. 340604)
Antigen Details
- Structure
- Type I single transmembrane protein with cytoplamic ITIM, associates with p85α of PI3K, Ig superfamily
- Distribution
-
Monocytes, granulocytes, and myeloid leukemia cell lines
- Function
- Inhibition of myeloid function
- Cell Type
- Monocytes, Granulocytes, Leukemia
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Marquez JA, et al. 2007. J. Mol. Bio. 367:310
2. Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690
3. Alvarez-Errico D, et al. 2007. J. Immunol. 178:808 - Gene ID
- 146722 View all products for this Gene ID
- UniProt
- View information about CD300F on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD300F Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human CD300F (IREM-1) | UP-D2 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-human CD300F (IREM-1)
Human peripheral blood monocytes stained with UP-D2 PE
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