Loading...

PE anti-human CD98 Recombinant Antibody

Pricing & Availability
Clone
2B6/CD98.Rec (See other available formats)
Regulatory Status
RUO
Other Names
4F2, FRP-1, RL-388
Isotype
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
A. 2B6-CD98Rec_PE_CD98_FC_100924
Human peripheral blood cells were stained with anti-human CD98 recombinant (clone 2B6/CD98.Rec) PE (left) or mouse IgG1, κ PE isotype control (right).
  • A. 2B6-CD98Rec_PE_CD98_FC_100924
    Human peripheral blood cells were stained with anti-human CD98 recombinant (clone 2B6/CD98.Rec) PE (left) or mouse IgG1, κ PE isotype control (right).
  • B. 2B6-CD98Rec_PE_CD98_FC_2_100924
    Human peripheral blood lymphocytes were stained with anti-human CD98 recombinant (clone 2B6/CD98.Rec) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
Cat # Size Price Quantity Check Availability Save
335511 25 tests 153 CHF
Check Availability


Need larger quantities of this item?
Request Bulk Quote
335512 100 tests 341 CHF
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD98, also known as 4F2 and FRP-1, is a 125 kD disulfide-linked heterodimer protein. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details

Structure
Disulfide-linked heterodimer, 80 kD and 45 kD reduced, 125 kD unreduced
Distribution

Broadly expressed on activated and transformed cells, not hematopoietic cell-specific. Lower levels on resting cells.

Function
Potential amino acid transporter (neutral and dibasic amino acids) also involved in the activation of lymphocytes and integrin signaling. May be a target antigen for NK cells.
Interaction
Actin, β1 integrins (α2β1, α3β1, α5β1, α6β1; minimally with α4β1)
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Leukocyte Typing VI. Kishimoto T, et al. (Eds.) Garland Publishing Inc. (1997)
  2. Bron C, et al. 1986. J. Immunol. 137:397.
  3. Lumadue JA, et al. 1987. Proc. Natl. Acad. Sci. 84:9204.
  4. Mastroberardino L, et al. 1998. Nature 395:288.
Gene ID
6520 View all products for this Gene ID
UniProt
View information about CD98 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 10.09.2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account