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PE anti-human FPR1 Antibody

Pricing & Availability
Clone
W15086B (See other available formats)
Regulatory Status
RUO
Other Names
fMet-Leu-Phe receptor 1, FMLP, FPR, fMLF-R
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
W15086B_PE_FPR1_Antibody_010418
Human peripheral blood leukocytes were stained with PE anti-human FPR1 (clone W15086B) (filled histogram) or PE mouse IgG1, κ isotype control (open histogram); data shown is gated on the granulocyte population.
  • W15086B_PE_FPR1_Antibody_010418
    Human peripheral blood leukocytes were stained with PE anti-human FPR1 (clone W15086B) (filled histogram) or PE mouse IgG1, κ isotype control (open histogram); data shown is gated on the granulocyte population.
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391605 25 tests 141 CHF
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391606 100 tests 341 CHF
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Description

FPR1 (Formyl Peptide Receptor 1), a G protein-coupled receptor consisting of seven transmembrane domains, is expressed on phagocytic cells and other cell types such as monocytes.  FPR1 is a high affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors.  Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release.  Endogenous peptide ligands for this receptor have also been identified.   FPR1 mediates the response to invasion of the host by microbial pathogens and is important in host defense and inflammation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length human FPR1 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2721634 (BioLegend Cat. No. 391605)
AB_2721634 (BioLegend Cat. No. 391606)

Antigen Details

Structure
Seven transmembrane domains, G-protein coupled receptor (GPCR)
Distribution

Monocytes, Neutrophils

Function
Chemotaxis
Ligand/Receptor
N-formylated peptides, Ac9-25, FAM19A4, Annexin A1
Cell Type
Monocytes, Neutrophils, Eosinophils
Biology Area
Immunology, Innate Immunity
Antigen References

1. Boulay F, et al. 1990. Biochemistry 29:11123.
2. Ye RD, et al. 2009. Pharmacol. Rev. 61:119.
3. Prossnitz ER, et al. 1999. Biochemistry 38:2240.
4. Wang W, et al. 2015. Cell Mol. Immunol. 12:615.

Gene ID
2357 View all products for this Gene ID
UniProt
View information about FPR1 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 0    Revision Date: 01.05.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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