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PE anti-mouse DcTRAIL-R2 Antibody

Pricing & Availability
Clone
mDcR2-1 (See other available formats)
Regulatory Status
RUO
Other Names
TNFRH2, Tnfrsf22, SOBa, Tnfrsf1al2, mDcTrailr2, tumor necrosis factor receptor superfamily member 22
Isotype
Armenian Hamster IgG
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Product Citations
publications
mDcR2_PE_051409.jpg
Mouse macrophage cell line RAW stained with mDcR2-1 PE
  • mDcR2_PE_051409.jpg
    Mouse macrophage cell line RAW stained with mDcR2-1 PE
See PE spectral data
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133703 25 µg 134 CHF
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Description Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 2 (mDcTRAIL-R2) is highly homologous to mDcTRAIL R1. It is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It is expressed on many cell types, including some tumor cells. It was reported that overexpression of mDcTRAIL-R2 did not induce caspase activation that is characteristic of death receptor signaling. mDcTRAIL-R2 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcTRAIL-R2 in apoptosis has not yet been completely clarified. Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
mDcTRAIL-R2-Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_1595525 (BioLegend Cat. No. 133703)

Antigen Details

Structure
GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain.
Distribution
Express on many types of cells, including some tumor cells.
Function
Appear to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis.
Ligand/Receptor
TRAIL
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
1. Schneider P, et al. 2003. J. Bio. Chem. 278(7):5444
2. Yagyu S, et al. 2008. Clin Cancer Res. 14 (21):7011
3. Ashkenazi A, et al. 1998. Science. 281:1305
Gene ID
79202 View all products for this Gene ID
UniProt
View information about DcTRAIL-R2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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