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PE anti-mouse PDC-TREM Antibody

Pricing & Availability
Clone
4A6 (See other available formats)
Regulatory Status
RUO
Other Names
Plasmacytoid dendritic cell-specific receptor
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
4A6_PE_1_062310
C57BL/6 mouse splenocytes activated overnight with CpG-A and stained with B220 FITC and 4A6 PE (top) or mouse IgG2a PE isotype control (bottom). The data shown is from the B220+CD11c+ cell population.
  • 4A6_PE_1_062310
    C57BL/6 mouse splenocytes activated overnight with CpG-A and stained with B220 FITC and 4A6 PE (top) or mouse IgG2a PE isotype control (bottom). The data shown is from the B220+CD11c+ cell population.
  • 4A6_PE_2_062310
See PE spectral data
Cat # Size Price Quantity Check Availability Save
139203 25 µg 129 CHF
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139204 100 µg 298 CHF
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Description

PDC-TREM, also known as plasmacytoid dendritic cell (PDC) -specific receptor, is a member of the TREM receptor family. It is a transmembrane protein composed of an extracellular region with one V-type Ig domain, a transmembrane region with a lysine residue, and a cytoplasmic domain with no recognized signaling motifs. The lysine present in the transmembrane region allows PDC-TREM to form a complex with DAP12 and Plexin-A1. PI3K and Erk 1/2 are involved in the signal transduction of this complex. PDC-TREM is expressed in TLR-activated PDCs and is involved in the production of IFN-α.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant soluble PDC-TREM
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western blot1.

Application References

(PubMed link indicates BioLegend citation)
  1. Watarai H, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2993. (WB)
  2. Rahim MM, et al. 2013. J. Immunol. 190:3994. PubMed.
Product Citations
  1. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  2. Naing A et al. 2019. Cell reports. 26(5):1242-1257 . PubMed
  3. Rahim M, et al. 2013. J Immunol. 190:3994. PubMed
RRID
AB_10613471 (BioLegend Cat. No. 139203)
AB_10613471 (BioLegend Cat. No. 139204)

Antigen Details

Structure
Member of the TREM receptor family. Type I protein composed of an extracellular region with a single V-type Ig domain, a transmembrane domain with a lysine residue and a cytoplasmic domain with no recognized signaling motifs.
Distribution
Expressed on TLR activated plasmacytoid dendritic cells (PDC)
Function
Signal transduction, induces the production of IFN-α
Interaction
DAP12, Plexin-A1, PI3K, Erk 1/2
Cell Type
Dendritic cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
Protein Kinases/Phosphatase
Antigen References

1. Jill W, et al. 2009. Curr. Opin. Immunol. 21:38.
2. Lanier LL. 2009. Immunol. Rev. 227:150.

Gene ID
328830 View all products for this Gene ID
UniProt
View information about PDC-TREM on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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