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PE anti-mouse RAE-1γ Antibody

Pricing & Availability
Clone
CX1 (See other available formats)
Regulatory Status
RUO
Other Names
Retinoid acid early inducible gamma
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
CX1_PE_021009.jpg
YAC-1 cell line stained with CX1 PE
  • CX1_PE_021009.jpg
    YAC-1 cell line stained with CX1 PE
See PE spectral data
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130107 50 µg 122 CHF
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Description

RAE-1 gamma is one of the five member RAE-family.Together with H60 they were identified as ligands for the mouse NKG2D molecules.Expression of RAE-1 is low or absent in normal adult tissue, but can be upreulgated by retinoid acid and constitutively expressed on some tumors.This antibody has weak crossreativity with RAE-1 alpha and RAE-1 beta.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse RAE-1 gamma transfected cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Lodoen M, et al. 2003. J. Exp. Med. 197:1245.
Product Citations
  1. Lis N, et al. 2021. J Cell Sci. 134:. PubMed
  2. Dubrot J, et al. 2021. Immunity. 54(3):571-585.e6. PubMed
RRID
AB_1227755 (BioLegend Cat. No. 130107)
Disclaimer

This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes contact The Regents of the University of California.

Antigen Details

Structure
RAE is a family of GPI-anchord surface protein consisting of alpha, beta, gamma, delta and epsilon. They share strong homology within the family and weak homology with MHC class 1 molecule.
Distribution

Expression of RAE-1 is low or absent on normal, adult tissue, but consititutively expressed on some tumors and can be induced by retinoid acid.

Function
As ligands for the mouse activating NKG2D expressed by NK cells
Ligand/Receptor
NKG2D
Biology Area
Immunology
Molecular Family
MHC Antigens
Antigen References

1. Cerwenka A, et al. 2000. Immnity. 12:721
2. Lodoen M, et al. 2003 J. Exp. Med. 197:1245
3. Diefenbach A, et al. 2001 Nature 413:165

Gene ID
66679 View all products for this Gene ID
UniProt
View information about RAE-1gamma on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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