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Purified anti-Annexin A1 Antibody

Pricing & Availability
Clone
BL28553 (See other available formats)
Regulatory Status
RUO
Other Names
ANXA1, Annexin A1
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
BL28553_Pure_Annexin-A1_Antibody_011519_updated
Western blot of purified anti-Annexin A1 antibody (clone BL28553). Lane 1: Molecular weight marker; Lane 2: 20 µg of HeLa cell lysate; Lane 3: 20 µg of NIH3T3 cell lysate; Lane 4: 20 µg of human spleen lysate. The blot was incubated with 0.1 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • BL28553_Pure_Annexin-A1_Antibody_011519_updated
    Western blot of purified anti-Annexin A1 antibody (clone BL28553). Lane 1: Molecular weight marker; Lane 2: 20 µg of HeLa cell lysate; Lane 3: 20 µg of NIH3T3 cell lysate; Lane 4: 20 µg of human spleen lysate. The blot was incubated with 0.1 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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855301 25 µg 106 CHF
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Description

Annexin A1 is a member of the annexin family of Ca2+-dependent phospholipid-binding proteins. Annexin A1 has been reported to play an important anti-inflammatory role by suppressing phospholipase A2 and blocking eicosanoid production. Expression of Annexin A1 may be  upregulated in the brains of Alzheimer’s diseases patients. Recent studies have demonstrated that Annexin A1 can induce the clearance and degradation of amyloid beta peptide, indicating its potential use as a therapeutic target for Alzheimer’s Disease.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2801208 (BioLegend Cat. No. 855301)

Antigen Details

Structure
Annexin A1 is a 346 amino acid protein with a molecular mass of ~ 39 kD.
Distribution

Tissue Distribution: Reproduction systems, gastrointestinal tract, lung, immune system, central, and peripheral nervous system.
Cellular distribution: Plasma membrane, cytosol, extracellular, nucleus, endosome, and extracellular.

Function
Annexin A1 plays an important role in innate immune response, clearance and degradation of amyloid beta peptide.
Interaction
Annexin A1 forms homodimers and may also interact with S100A11, DYSF, and EGFR.
Biology Area
Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Synaptic Biology
Antigen References
  1. Rentero C, et al. 2018. Int j Mol Sci. 19(5)
  2. Perucci LO, et al. 2017. Expert Opin Ther Targets. 21(9):879
  3. Boudhraa Z, et al. 2016. Clin Sci. 130(4):205
Gene ID
301 View all products for this Gene ID 16952 View all products for this Gene ID
UniProt
View information about Annexin A1 on UniProt.org
Go To Top Version: 2    Revision Date: 01.28.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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